PHR1369
Thiamine pyrophosphate
Pharmaceutical Secondary Standard; Certified Reference Material
동의어(들):
Thiamine pyrophosphate, Aneurinepyrophosphoric acid, Cocarboxylase, Thiamine pyrophosphate chloride
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C12H19ClN4O7P2S
CAS 번호:
Molecular Weight:
460.77
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
205-836-1
Beilstein/REAXYS Number:
3875902
MDL number:
InChI key
YXVCLPJQTZXJLH-UHFFFAOYSA-N
InChI
1S/C12H18N4O7P2S.ClH/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);1H
SMILES string
CC1=C(CCOP(OP(O)(O)=O)(O)=O)SC=[N+]1CC2=C(N)N=C(C)N=C2.[Cl-]
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to USP 1656002
API family
thiamine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
-10 to -25°C
Quality Level
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General description
Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Thiamine pyrophosphate is a coenzyme of transketolase that catalyzes the cleavage of ribulose-5-phosphate; thereby forming D-glyceraldehyde-3-phosphate. This reaction requires the addition of an acceptor aldehyde such as ribose-5-phosphate, glyceraldehye or glycolaldehyde.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA1473 in the slot below. This is an example certificate only and may not be the lot that you receive.
wgk
WGK 1
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
저장 등급
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Thiamine pyrophosphate-catalyzed enzymatic decarboxylation of -oxo acids.
J Ullrich et al.
Vitamins and hormones, 28, 365-398 (1970-01-01)
Darcy McRose et al.
The ISME journal, 8(12), 2517-2529 (2014-08-30)
Vitamin B1 (thiamine pyrophosphate, TPP) is essential to all life but scarce in ocean surface waters. In many bacteria and a few eukaryotic groups thiamine biosynthesis genes are controlled by metabolite-sensing mRNA-based gene regulators known as riboswitches. Using available genome
Nia L Marrott et al.
The Biochemical journal, 463(3), 405-412 (2014-08-05)
The four-component polypeptides of the 2-oxoacid dehydrogenase complex from the thermophilic archaeon Thermoplasma acidophilum assemble to give an active multienzyme complex possessing activity with the branched-chain 2-oxoacids derived from leucine, isoleucine and valine, and with pyruvate. The dihydrolipoyl acyl-transferase (E2)
E M Dunbar et al.
Investigational new drugs, 32(3), 452-464 (2013-12-04)
Recurrent malignant brain tumors (RMBTs) carry a poor prognosis. Dichloroacetate (DCA) activates mitochondrial oxidative metabolism and has shown activity against several human cancers. We conducted an open-label study of oral DCA in 15 adults with recurrent WHO grade III -
Hetalben Patel et al.
Biochemistry, 53(13), 2145-2152 (2014-03-19)
Identification of enzyme-bound intermediates via their spectroscopic signatures, which then allows direct monitoring of the kinetic fate of these intermediates, poses a continuing challenge. As an electrophilic covalent catalyst, the thiamin diphosphate (ThDP) coenzyme forms a number of noncovalent and
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