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V8388

Vincristine sulfate

Name: Vincristine sulfate
Brand: SIAL

meets USP testing specifications

동의어(들):

Vincristine sulfate salt, 22-Oxovincaleukoblastine sulfate salt, Leurocristine sulfate salt, VCR

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₄₆H₅₆N₄O₁₀ · H₂SO₄

CAS 번호:

2068-78-2

Molecular Weight:

923.04

UNSPSC Code:

12352210

NACRES:

NA.21

PubChem Substance ID:

24900771

EC Number:

218-190-0

Beilstein/REAXYS Number:

3924631

MDL number:

MFCD00084729

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속성

Quality Level

200

agency

USP/NF, meets USP testing specifications

solubility

ethanol: slightly soluble, methanol: soluble, water: freely soluble

antibiotic activity spectrum

neoplastics

application(s)

pharmaceutical (small molecule)

mode of action

protein synthesis | interferes

storage temp.

−20°C

SMILES string

OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1

InChI

1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

InChI key

AQTQHPDCURKLKT-PNYVAJAMSA-N

설명

General description

Vincristine sulfate is an alkaloid present in Cantharanthus roseus.

Application

Widely used in cancer research. In studies on multi-drug resistance. Used to inhibit cell cycle progression at M-phase. Used to inhibit monoamine oxidase (MAO).

Vincristine sulfate has been used:

as a positive control in potato disc anti-tumor bioassay
as a standard cytotoxic agent
to treat cells for manipulation of the microtubule network

Biochem/physiol Actions

Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.