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Galangin

Name: Galangin
Brand: SIGMA

autophagy inducing flavonoid

동의어(들):

3,5,7-Trihydroxyflavone, Norizalpinin

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₅H₁₀O₅

CAS 번호:

548-83-4

Molecular Weight:

270.24

UNSPSC Code:

41116107

NACRES:

NA.79

PubChem Substance ID:

57648294

EC Number:

208-960-4

Beilstein/REAXYS Number:

272179

MDL number:

MFCD00006833

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도움 문의

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

yellow

mp

214-215 °C (lit.)

SMILES string

Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3

InChI

1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H

InChI key

VCCRNZQBSJXYJD-UHFFFAOYSA-N

Gene Information

human ... ADORA2A(135), ADORA3(140), CYP1A2(1544)
rat ... Adora1(29290), Adora2a(25369)

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General description

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.

Application

Galangin has been used:

as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity
to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes
as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy

Biochem/physiol Actions

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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문서 라이브러리 방문

Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents.

Jung-Jin Lee et al.

Scientific reports, 7(1), 8207-8207 (2017-08-16)

In clinical pathology, stent interposition is used to treat vascular disease but can lead to restenosis. Drug-eluting stents (DES) are most commonly used to suppress restenosis but can also have side effects. Therefore, we investigated the anti-proliferative effect and its

The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor

Ciolino HP and Yeh GC

British Journal of Cancer, 79(9), 1340-1340 (1999)

In Silico Target Identification of Galangin, as an Herbal Flavonoid against Cholangiocarcinoma.

Brinda Balasubramanian et al.

Molecules (Basel, Switzerland), 27(14) (2022-07-28)

Cholangiocarcinoma (CCA) is a heterogenous group of malignancies in the bile duct, which proliferates aggressively. CCA is highly prevalent in Northeastern Thailand wherein it is associated with liver fluke infection, or Opisthorchis viverrini (OV). Most patients are diagnosed in advanced

α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study.

Carina Proença et al.

Journal of enzyme inhibition and medicinal chemistry, 32(1), 1216-1228 (2017-09-22)

α-Glucosidase inhibitors are described as the most effective in reducing post-prandial hyperglycaemia (PPHG) from all available anti-diabetic drugs used in the management of type 2 diabetes mellitus. As flavonoids are promising modulators of this enzyme's activity, a panel of 44

Acute consumption of flavan-3-ol-enriched dark chocolate affects human endogenous metabolism

Ostertag LM, et al.

Journal of Proteome Research, 16(7), 2516-2526 (2017)

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Dietary Antioxidants

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