30320
Cytidine 5′-triphosphate disodium salt hydrate
≥90.0% (HPLC), solid
동의어(들):
5-CTP-Na2, CTP
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C9H14N3Na2O14P3 · xH2O
CAS 번호:
Molecular Weight:
527.12 (anhydrous basis)
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Beilstein/REAXYS Number:
3582735
Assay:
≥90.0% (HPLC)
Form:
solid
Solubility:
H2O: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
제품 이름
Cytidine 5′-triphosphate disodium salt hydrate, ≥90.0% (HPLC)
Quality Level
assay
≥90.0% (HPLC)
form
solid
impurities
≤12% water
solubility
H2O: 50 mg/mL, clear, colorless
shipped in
wet ice
storage temp.
−20°C
SMILES string
O.[Na+].[Na+].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O
InChI
1S/C9H16N3O14P3.2Na.H2O/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18);;;1H2/q;2*+1;/p-2/t4-,6-,7-,8-;;;/m1.../s1
InChI key
IJMSOWKYYIROGP-LLWADOMFSA-L
Application
Cytidine 5γ-triphosphate (CTP) is used to synthesize RNA by various RNA polymerases. Cytidine 5γ-triphosphate (CTP) is a substrate for CMP-neuNAc synthetase(s) which produce CMP-neuNAc used in sialylation reactions. As a substrate of CTP:phosphocholine cytidylyltransferase(s) (CT), CTP supports the formation of phosphatidylcholine via the formation of CDP-choline.
Cytidine 5′-triphosphate disodium salt hydrate has been used:
- in the oligonucleotide synthesis for silver nanoclusters interaction studies
- as an anion source for fluorescence emission and titration curve-analysis of hypocrellin A-zinc(II) complex
- in fluorescence emission experiments of copper(II)–2,6-bis(2-benzimidazolyl)pyridine complex
Biochem/physiol Actions
Cytidine 5′-triphosphate (CTP) is essential for the synthesis of DNA and is a mediator of many physiological processes in living systems. It is crucial for the dolichol phosphorylation, cholesterol transport and is involved in the allosteric regulation of aspartate transcarbamylase. It is also used in the treatment of disease related brain.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
Melissa A MacKinnon et al.
The Journal of biological chemistry, 284(11), 7376-7384 (2009-01-15)
Phosphatidylcholine is the major phospholipid in eukaryotic cells. There are two main pathways for the synthesis of phosphatidylcholine: the CDP-choline pathway present in all eukaryotes and the phosphatidylethanolamine methylation pathway present in mammalian hepatocytes and some single celled eukaryotes, including
Selective fluorometric detection of pyrophosphate and stringent alarmone with copper (II)-2, 6-bis (2-benzimidazolyl) pyridine complex
Zhao XJ and Huang CZ
Biosensors And Bioelectronics, 30(1), 282-286 (2011)
Ratiometric Detection of Adenosine-5?-triphosphate (ATP) and Cytidine-5?-triphosphate (CTP) with a Fluorescent Spider-Like Receptor in Water
Gupta AK, et al.
European Journal of Organic Chemistry, 2015(1), 122-129 (2015)
Highly selective detection of bacterial alarmone ppGpp with an off-on fluorescent probe of copper-mediated silver nanoclusters
Zhang P, et al.
Biosensors And Bioelectronics, 49(1), 433-437 (2013)
U Edwards et al.
FEMS microbiology letters, 75(2-3), 161-166 (1992-09-15)
The CMP-N-acetylneuraminic acid (CMP-NeuNAc) synthetase gene of Neisseria meningitidis group B is located on a 2.3-kb EcoRI fragment within the cps gene cluster. Nucleotide sequence determination of the gene encoding the CMP-NeuNAc synthetase revealed a 515-bp open reading frame that
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