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Merck

A4034

(+)-Sodium L-ascorbate

powder, BioReagent, suitable for cell culture

동의어(들):

L(+)-Ascorbic acid sodium salt, Vitamin C sodium salt

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C6H7NaO6
CAS 번호:
Molecular Weight:
198.11
NACRES:
NA.75
PubChem Substance ID:
eCl@ss:
34058010
UNSPSC Code:
12352205
EC Number:
205-126-1
MDL number:
Beilstein/REAXYS Number:
3767246
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도움 문의


biological source

synthetic (organic)

Quality Level

product line

BioReagent

assay

≥98%

form

powder

mol wt

Mw 198.11 g/mol

technique(s)

cell culture | mammalian: suitable, cell culture | plant: suitable

color

white to off-white

mp

220 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

SMILES string

[Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]

InChI

1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1

InChI key

PPASLZSBLFJQEF-RXSVEWSESA-M

General description

(+)-Sodium L-ascorbate (SA) is a potential antioxidant and is a derivative of vitamin C (L-ascorbic acid). It is widely used as a food additive. In addition, SA enhances growth retardation activity of bleomycin sulfate, R020-1724 (an inhibitor of cyclic nucleotide phosphodiesterase), prostaglandin E1 and sodium butyrate agents on neuroblastoma cells in culture. Elevated levels of SA induces two-stage urinary bladder carcinogenesis in rats. sodium L-ascorbate in combination with collagenogenesis inhibitors is used to treat dermal scars and keloids.

Application

Used for preparation of plant extracts; reductant for the isolation of chloroplasts.
(+)-Sodium L-ascorbate has been used:
  • to produce H2O2 in cell culture media
  • as a reducing agent for a cell-permeable artificial electron donor, N,N,N′,N′-tetramethyl-p-phenylenediamine (TMPD)
  • to study its effect on production of collagen and elastic fibers in fibroblasts cultures derived from normal human skin and dermal fat

Biochem/physiol Actions

Antioxidant


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저장 등급

11 - Combustible Solids

wgk

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)



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문서 라이브러리 방문


문서

Importance and uses of ascorbate in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.


Artefacts in cell culture: alpha-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media
Long LH and Halliwell B
Biochemical and Biophysical Research Communications, 406(1), 20-24 (2011)
Artefacts in cell culture: pyruvate as a scavenger of hydrogen peroxide generated by ascorbate or epigallocatechin gallate in cell culture media
Long LH and Halliwell B
Biochemical and Biophysical Research Communications, 388(4), 700-704 (2009)
Promoting effects of sodium L-ascorbate on two-stage urinary bladder carcinogenesis in rats
Fukushima S, et al.
Cancer Research, 43(9), 4454-4457 (1983)