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Merck

A4393

R-(−)-Apomorphine hydrochloride hemihydrate

calcined, ≥98% (with NaOH, titration)

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
C17H17NO2 · HCl · 1/2H2O
CAS 번호:
41372-20-7
Molecular Weight:
312.79
NACRES:
NA.77
PubChem Substance ID:
24278821
UNSPSC Code:
12352210
EC Number:
206-243-0
MDL number:
MFCD00150904
Assay:
≥98% (with NaOH, titration)
Form:
calcined, (Powder to Crystalline Powder)
Quality level:
200
Storage condition:
protect from light, under inert gas

주요 문서

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Quality Level

200

assay

≥98% (with NaOH, titration)

form

calcined, (Powder to Crystalline Powder)

storage condition

protect from light, under inert gas

color

white to gray

mp

285-287 °C (lit.)

solubility

H2O: ~10 mg/mL, clear, yellow-green

SMILES string

Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68

InChI

1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1

InChI key

CXWQXGNFZLHLHQ-DPFCLETOSA-N

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

관련 카테고리

Application

R-(-)-Apomorphine hydrochloride hemihydrate has been used as a dopamine receptor agonist to study its effects of rotational behavior in rat models of Parkinson′s disease.

Biochem/physiol Actions

R-(−)-Apomorphine acts as a non-selective D1 and D2 dopamine receptor agonist. It shows therapeutic effects against Parkinson′s disease and male erectile dysfunction. R-(−)-Apomorphine also shows neuroprotective, radical scavenging, and emetic effects. Apomorphine stimulates the brain chemoreceptor trigger zone. It stimulates the chemoreceptor trigger zone in the brain.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
098K1217
048K1474
067K3679
085K1223
026K1093

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Qian Li et al.
Neuron, 76(5), 1030-1041 (2012-12-12)
Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN)
Kristina Malinovskaja et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 83(3), 477-484 (2012-12-05)
The objective of this study was to test a drug delivery system that combines iontophoresis and cation-exchange fibers as drug matrices for the controlled transdermal delivery of antiparkinsonian drug apomorphine. Positively charged apomorphine was bound to the ion-exchange groups of
Fumitoshi Kodaka et al.
European journal of nuclear medicine and molecular imaging, 40(4), 574-579 (2012-12-15)
Dopamine D receptors (DRs) have two affinity states for endogenous dopamine, referred to as high-affinity state (D ), which has a high affinity for endogenous dopamine, and low-affinity state (D ). The density of D can be measured with (R)-2-CHO-N-n-propylnorapomorphine
Yanpeng Yuan et al.
Theranostics, 8(17), 4679-4694 (2018-10-04)
Autologous neural stem cells (NSCs) may offer a promising source for deriving dopaminergic (DA) cells for treatment of Parkinson's disease (PD). Methods: By using Sendai virus, human peripheral blood mononuclear cells (PBMNCs) were reprogrammed to induced NSCs (iNSCs), which were
Anthony C Vernon et al.
Methods in molecular biology (Clifton, N.J.), 711, 487-510 (2011-02-01)
Neurotoxin-based rodent models of Parkinson's disease (PD) are widely used for pre-clinical evaluation of novel therapeutics for PD and have provided insights into mechanisms underlying motor dysfunction and nigrostriatal degeneration in PD. Predominantly, magnetic resonance imaging (MRI) studies in such
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