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A4978

Alendronate sodium trihydrate

Name: Alendronate sodium trihydrate
Brand: SIGMA

≥97% (NMR), bone resorption inhibitor, powder

동의어(들):

4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₄H₁₂NaNO₇P₂ · 3 H₂O

CAS 번호:

121268-17-5

Molecular Weight:

325.12

UNSPSC Code:

41106300

PubChem Substance ID:

24724391

NACRES:

NA.77

MDL number:

MFCD01748233

Assay:

≥97% (NMR)

Form:

powder

Quality level:

100

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속성

제품 이름

Alendronate sodium trihydrate, ≥97% (NMR), powder

Quality Level

100

assay

≥97% (NMR)

form

powder

color

white

solubility

water, double-distilled: 10 mg/mL

storage temp.

−20°C

SMILES string

[Na+].[H]O[H].[H]O[H].[H]O[H].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O

InChI

1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1

InChI key

DCSBSVSZJRSITC-UHFFFAOYSA-M

Gene Information

human ... FDPS(2224)

설명

Application

Alendronate sodium trihydrate has been used:

for calcium phosphate nanoparticles (nCaP)/ bisphosphonate (BP) coating on titanium implants and analyze its osteogenic capacity
in osteogenic differentiation of human bone marrow stromal cells (hBMSCs) isolated from aged osteoporosis patients- and healthy-person
to treat osteoblast progenitor cells and osteoblasts and study their effect on osteoblast behaviors using conventional assays and simple digital image analysis

Biochem/physiol Actions

Alendronate is a nitrogen-containing bisphosphonate that is known to hinder the mevalonate pathway and limit osteoclastic function and activity. Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor, and CD45 protein tyrosine phosphatase inhibitor.

Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC₅₀= 460 nM); CD45 protein tyrosine phosphatase inhibitor.