A5268
Alcian Blue 8GX
powder
동의어(들):
Alcian Blue, Ingrain Blue 1
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C56H68Cl4CuN16S4
CAS 번호:
Molecular Weight:
1298.86
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
251-705-7
Colour Index Number:
74240
MDL number:
InChI key
CKLBXIYTBHXJEH-UHFFFAOYSA-J
InChI
1S/C56H68N16S4.4ClH.Cu/c1-65(2)53(66(3)4)73-29-33-17-21-37-41(25-33)49-57-45(37)62-50-43-27-35(31-75-55(69(9)10)70(11)12)19-23-39(43)47(59-50)64-52-44-28-36(32-76-56(71(13)14)72(15)16)20-24-40(44)48(60-52)63-51-42-26-34(18-22-38(42)46(58-51)61-49)30-74-54(67(5)6)68(7)8;;;;;/h17-28H,29-32H2,1-16H3;4*1H;/q+2;;;;;+2/p-4
form
powder
composition
Dye content, 45-65%
technique(s)
microbe id | staining: suitable
color
blue
solubility
H2O: 1 mg/mL
εmax
425 at 615-630 nm in water
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
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General description
Alcian Blue 8GX, also known as Ingrain Blue 1, is a basic copper phthalocyanine dye whose copper content imparts a blue color. It is tetravalent, cationic, and water-soluble in nature. It forms salt linkages with the acid groups of acid mucopolysaccharides.
Application
- Alcian Blue 8GX has been used for the staining and precipitation of glycosaminoglycans and as a heteroglycan stain for neutral, sulfated, and phosphated mucopolysaccharides and glycosaminoglycans in tissues such as cartilage and extracellular matrices.
- It has been employed in the in vivo visualization of intravascular Bonghan ducts and corpuscles in murine models.
- It has been used to develop a novel histochemical staining method to assess multiple respiratory parameters in various species.
Biochem/physiol Actions
The Alcian blue staining is easily combined with the Periodic acid-Schiff (PAS) reaction. In the tissue, acid mucosubstances are stained selectively and nuclear fast red is commonly used as counterstain. In combination with the PAS reaction, non-substituted polysaccharides, neutral mucopolysaccharides, muco- and glycoproteins, and glycol- and phospholipids can be visualized in addition. An Acetic acid-Alcian blue solution is used for the staining, whereby carboxylated and sulfatic proteoglycans are selectively stained when a pH of 2.5 is applied. The differentiation between carboxyl and sulfate groups is only possible at pH 1.
Features and Benefits
Desired staining patterns can be obtained by manipulating pH and salt concentrations.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Exposure of human cartilage tissue to low concentrations of blood for a short period of time leads to prolonged cartilage damage: an in vitro study.
Jansen NW, et al.
Arthritis and Rheumatism, 56, 199-207 (2007)
Selective COX-2 inhibition prevents proinflammatory cytokine-induced cartilage damage.
Mastbergen SC, et al.
Rheumatology (Oxford, England), 41, 801-808 (2002)
Replacement of the medial tibial plateau by a metallic implant in a goat model.
Custers RJ, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 28, 429-435 (2010)
Kristin V T Engebretsen et al.
Journal of molecular and cellular cardiology, 76, 148-157 (2014-08-30)
Pressure overload-induced TGF-β signaling activates cardiac fibroblasts (CFB) and leads to increased extracellular matrix (ECM) protein synthesis including fibrosis. Excessive ECM accumulation may in turn affect cardiac function contributing to development of heart failure. The aim of this study was
The quantitative determination of glycosaminoglycans in urine with Alcian Blue 8GX.
Whiteman P
The Biochemical Journal, 131, 351-357 (1973)
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