A5282
DL-2-Amino-5-phosphonopentanoic acid
≥98% (TLC), solid, NMDA receptor antagonist
동의어(들):
5-Phosphono-DL-norvaline, DL-2-Amino-5-phosphonovaleric acid, AP-5, APV
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C5H12NO5P
CAS 번호:
Molecular Weight:
197.13
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
2446389
Form:
solid
Quality level:
제품 이름
DL-2-Amino-5-phosphonopentanoic acid, solid
InChI
1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
SMILES string
NC(CCCP(O)(O)=O)C(O)=O
InChI key
VOROEQBFPPIACJ-UHFFFAOYSA-N
form
solid
color
white
solubility
0.1 M NaOH: 4 mg/mL
H2O: 5.6 mg/mL
organic solvents: insoluble
Quality Level
Gene Information
rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)
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Application
DL-2-Amino-5-phosphonopentanoic acid has been used:
- in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses
- used in growth medium for inhibition of electrical activity in the neuronal network
- used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
- used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)
Biochem/physiol Actions
Anticonvulsant; potent and selective NMDA receptor antagonist.
Disclaimer
Hygroscopic
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Engineered neuronal circuits shaped and interfaced with carbon nanotube microelectrode arrays
Shein M, et al.
Biomedical Microdevices, 11(2), 495-501 (2009)
Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation
Weitlauf C, et al.
The Journal of Neuroscience, 25(37), 8386-8390 (2005)
Ryota Kobayashi et al.
Frontiers in computational neuroscience, 3, 9-9 (2009-08-12)
Information is transmitted in the brain through various kinds of neurons that respond differently to the same signal. Full characteristics including cognitive functions of the brain should ultimately be comprehended by building simulators capable of precisely mirroring spike responses of
Maria José Diógenes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(34), 11750-11762 (2012-08-24)
Parkinson's disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of α-synuclein (a-syn) in various brain regions is the major pathological hallmark. Indeed, the motor symptoms in PD are
Marijn van Wingerden et al.
Neuron, 76(4), 813-825 (2012-11-28)
Neural activity in orbitofrontal cortex has been linked to flexible representations of stimulus-outcome associations. Such value representations are known to emerge with learning, but the neural mechanisms supporting this phenomenon are not well understood. Here, we provide evidence for a
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