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Merck

A6279

Aprotinin

3-7 TIU/mg protein, saline solution

동의어(들):

BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C284H432N84O79S7
CAS 번호:
9087-70-1
Molecular Weight:
6511.44
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00130541

주요 문서

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제품 이름

Aprotinin from bovine lung, saline solution, 3-7 TIU/mg protein

SMILES string

S1SCC2NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C5NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C9N(CCC9)C(=O)CNC(=O)C(NC(=O)C(NC(=O)C%11N(CCC%11)C(=O

InChI

1S/C284H432N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291)378)246(41

InChI key

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

biological source

bovine

sterility

aseptically filled

form

saline solution

specific activity

3-7 TIU/mg protein

mol wt

~6,500

solubility

H2O: soluble >10 mg/mL

UniProt accession no.

P00974

storage temp.

2-8°C

Quality Level

300

Gene Information

cow ... PTI(404172)

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General description

Aprotinin is a 58 amino acid-long protein, with a calculated molecular weight of 6512 Da, that acts as a serine protease inhibitor. Known also as bovine pancreatic trypsin inhibitor (BPTI), aprotinin inhibits serine proteases such as chymotrypsin, kallikrein, plasmin and trypsin.

Application

Aprotinin is largely used as an inhibitor of trypsin.

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Preparation Note

This product is an aseptically filled solution in 0.9% NaCl and 0.9% benzyl alcohol. It has an activity of 3-7 TIU/mg protein and 3-21 TIU/mL solution.

Other Notes

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.

Disclaimer

Aprotinin products should be stored at 2-8°C.

저장 등급

12 - Non Combustible Liquids

wgk

nwg

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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시험 성적서(COA)

Lot/Batch Number
SLCJ9493
SLCG5705
SLCC9045
SLBZ9668
SLBX1758

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문서 라이브러리 방문

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Tyrosine kinases drive the proliferation and survival of many human cancers. Thus profiling the global state of tyrosine phosphorylation of a tumor is likely to provide a wealth of information that can be used to classify tumors for prognosis and
Association between use of antenatal magnesium sulfate in preterm labor and adverse health outcomes in infants.
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American journal of obstetrics and gynecology, 189(2), 613-613 (2003-10-04)
William M Maniscalco et al.
American journal of physiology. Lung cellular and molecular physiology, 282(4), L811-L823 (2002-03-07)
Proper formation of the pulmonary microvasculature is essential for normal lung development and gas exchange. Lung microvascular development may be disrupted by chronic injury of developing lungs in clinical diseases such as bronchopulmonary dysplasia. We examined microvascular development, angiogenic growth
E M Benkhart et al.
Journal of immunology (Baltimore, Md. : 1950), 165(3), 1612-1617 (2000-07-21)
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문서

Aprotinin

While aprotinin and bovine pancreatic trypsin inhibitor (BPTI) are the same protein sequence, the term aprotinin is typically used when describing the protein derived from bovine lung.

프로토콜

Enzymatic Assay of Aprotinin

Objective: To standardize a procedure for the enzymatic assay of Aprotinin.

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