A9730
Adefovir dipivoxil
동의어(들):
9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C20H32N5O8P
CAS 번호:
Molecular Weight:
501.47
NACRES:
NA.76
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
biological source
synthetic
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
ethanol: 50 mg/mL
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
storage temp.
−20°C
SMILES string
CC(C)(C)C(=O)OCOP(=O)(COCCn1cnc2c(N)ncnc12)OCOC(=O)C(C)(C)C
InChI
1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
InChI key
WOZSCQDILHKSGG-UHFFFAOYSA-N
Biochem/physiol Actions
Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog that works by blocking reverse transcriptase. It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification. Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1). Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages .
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
저장 등급
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Julien Delmas et al.
Antimicrobial agents and chemotherapy, 46(2), 425-433 (2002-01-18)
The elimination of viral covalently closed circular DNA (CCC DNA) from the nucleus of infected hepatocytes is an obstacle to achieving sustained viral clearance during antiviral therapy of chronic hepatitis B virus (HBV) infection. The aim of our study was
A Takeda et al.
Journal of viral hepatitis, 14(2), 75-88 (2007-01-25)
Standard treatments for chronic hepatitis B (CHB) include interferon-alpha (IFN-alpha) and lamivudine (LAM), but these are associated with adverse effects and viral resistance, respectively. The aim of this systematic review and economic evaluation was to assess the clinical effectiveness and
M Danta et al.
International journal of clinical practice, 58(9), 877-886 (2004-11-09)
Adefovir dipivoxil (ADF) is a novel acyclic nucleoside analogue that has recently been approved for the treatment of chronic hepatitis B virus (HBV). Adefovir was initially assessed at higher doses for the treatment of human immunodeficiency virus (HIV) infection. However
Andrea Puhar et al.
PloS one, 3(10), e3564-e3564 (2008-10-30)
Anthrax edema toxin (EdTx) is an adenylate cyclase which operates in the perinuclear region of host cells. However, the action of EdTx is poorly understood, especially at molecular level. The ability of EdTx to modulate cAMP-dependent signaling was studied in
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Yuequan Shen, Natalia L. Zhukovskaya, et. Al
Proceedings of the National Academy of Sciences of the USA, 101, 3234-3247 (2004)
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