B1793

Bafilomycin A1

Name: Bafilomycin A1
Brand: SIGMA

from Streptomyces griseus, ≥90% (HPLC), film, V-ATPase inhibitor

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₃₅H₅₈O₉

CAS 번호:

88899-55-2

Molecular Weight:

622.83

UNSPSC Code:

12352200

PubChem Substance ID:

24891613

NACRES:

NA.77

Beilstein/REAXYS Number:

4730700

MDL number:

MFCD06795130

Assay:

≥90% (HPLC)

Form:

film

Quality level:

300

주요 문서

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제품 이름

Bafilomycin A1 from Streptomyces griseus, ≥90% (HPLC)

SMILES string

CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C=C(OC)C(=O)OC1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@H](O2)C(C)C

InChI

1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChI key

XDHNQDDQEHDUTM-JQWOJBOSSA-N

assay

≥90% (HPLC)

form

film

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

−20°C

Quality Level

300

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Application

Bafilomycin A1 has been used:

as an autophagy inhibitor to study its effects on hepatic steatosis in human hepatocytes
as a vacuolar-type H⁺ -ATPase inhibitor to study its effects on the cell viability, percentage of PI-positive cells, and glucose-stimulated insulin secretion (GSIS) in mice INS-1 cells
as a vacuolar-type H⁺ -ATPase inhibitor to study its effects on tau degradation in human SH-SY5Y cells

Biochem/physiol Actions

A specific inhibitor of vacuolar type H⁺-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.

Bafilomycin A1 inhibits autophagosome-lysosome fusion and autolysosome acidification, the steps involved in the autophagic process that is required for maintaining functional autophagic flux and cellular homeostasis.

Specific inhibitor of vacuolar type H⁺-ATPase (V-ATPase).

General description

Chemical structure: macrolide

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

저장 등급

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.

Jens Niewoehner et al.

Neuron, 81(1), 49-60 (2014-01-15)

Although biotherapeutics have vast potential for treating brain disorders, their use has been limited due to low exposure across the blood-brain barrier (BBB). We report that by manipulating the binding mode of an antibody fragment to the transferrin receptor (TfR)

The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase.

T Umata et al.

The Journal of biological chemistry, 265(35), 21940-21945 (1990-12-15)

The role of vacuolar-type H(+)-ATPase (V-ATPase) in the cytotoxic action of diphtheria toxin (DT) was studied by using bafilomycin A1, a specific inhibitor of V-ATPase. Studies with acridine orange showed that the acidification of intracellular acidic compartments was inhibited strongly

Cpvma1, a Vacuolar H+-ATPase Catalytic Subunit of Cryphonectria parasitica, is Essential for Virulence and Hypovirus RNA Accumulation.

Ru Li et al.

Phytopathology, 109(8), 1417-1424 (2019-03-13)

The vacuolar H+-ATPases (V-ATPases) are conserved ATP-dependent proton pumps that acidify intracellular compartments in eukaryotic cells. The role of Cpvma1, a V-ATPase catalytic subunit A of Cryphonectria parasitica, was investigated by generating cpvma1-overexpressing and cpvma1-silenced strains. The mutant strains were

The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.

Feng-Xia Guo et al.

Cell death and differentiation, 26(9), 1670-1687 (2019-01-27)

Atherosclerosis is a progressive, chronic inflammation in arterial walls. Long noncoding RNAs (lncRNAs) participate in inflammation, but the exact mechanism in atherosclerosis is unclear. Our microarray analyses revealed that the levels of lncRNA-FA2H-2 were significantly decreased by oxidized low-density lipoprotein

Kun Wang et al.

International journal of molecular sciences, 20(14) (2019-07-25)

The main mechanistic function of most chemotherapeutic drugs is mediated by inducing mitochondria-dependent apoptosis. Tumor cells usually respond to upregulate autophagy to eliminate impaired mitochondria for survival. Hypothetically, inhibiting autophagy might promote mitochondria-dependent apoptosis, thus enhancing the efficacy of chemotherapeutic

모든 관련된 서류 보기

문서

Autophagy in Cancer Promotes Therapeutic Resistance

We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance

Bafilomycin A1

from Streptomyces griseus, ≥90% (HPLC), film, V-ATPase inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

SMILES string

InChI

InChI key

assay

form

antibiotic activity spectrum

mode of action

storage temp.

Quality Level

관련 카테고리

설명

Application

Biochem/physiol Actions

General description

Other Notes

안전성 정보

저장 등급

wgk

ppe

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