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C0869

Celastrol

Name: Celastrol
Brand: SIGMA

≥98% (HPLC), solid, antioxidant

동의어(들):

10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₉H₃₈O₄

CAS 번호:

34157-83-0

Molecular Weight:

450.61

UNSPSC Code:

12352200

PubChem Substance ID:

329774823

NACRES:

NA.77

MDL number:

MFCD03424073

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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속성

제품 이름

Celastrol, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

red

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

−20°C

SMILES string

CC1=C(O)C(=O)C=C2C1=CC=C3[C@@]2(C)CC[C@@]4(C)[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(O)=O

InChI

1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1

InChI key

KQJSQWZMSAGSHN-JJWQIEBTSA-N

설명

Application

Celastrol has been:

used intraperitoneally to inject into experimental mice to study its role in nonalcoholic fatty liver disease (NAFLD)
used in culture medium to study its effect on lipopolysaccharide-induced inflammatory injury in human keratinocyte cell culture
used to study its effect in vitro and in vivo in VCaP cells

Biochem/physiol Actions

Celastrol is a quinone methide triterpene naturally present in Tripterygium wilfordii. It is useful in treating rheumatoid arthritis. Celastrol prevents the action of proteasome and nuclear factor Κb.

Celastrol is a potent antioxidant, and anti-inflammatory agent.

Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).

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저장 등급

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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시험 성적서(COA)

Lot/Batch Number

098K4711

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