C1608
Monoclonal Anti-Cellular Retinoic Acid Binding Protein 1 antibody produced in mouse
clone C-1, ascites fluid, buffered aqueous solution
동의어(들):
Anti-CRABP 1
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
C-1, monoclonal
Application:
ELISA (i), WB
Citations:
7
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
C-1, monoclonal
form
buffered aqueous solution
mol wt
antigen 16 kDa
species reactivity
feline, turtle, monkey, rabbit, bovine, human, rat, chicken
should not react with
(chameleon), frog, goldfish
technique(s)
indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CRABP1(1381)
rat ... Crabp1(25061)
관련 카테고리
General description
Cellular retinoic acid-binding protein 1 is a protein encoded by the CRABP1 gene in humans. It encodes a specific binding protein for a vitamin A family member. It is also referred as RBP5, CRABP, CRABPI and CRABP-I.
Immunogen
performic acid oxidized CRABP 1, purified from bovine retina.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Monoclonal Anti-Cellular Retinoic Acid Binding Protein 1 antibody produced in mouse is suitable for the following applications:
- indirect ELISA
- western blotting at a dilution of 1:1000
- immunofluorescence at a working dilution of 1:250
Biochem/physiol Actions
Cellular retinoic acid-binding protein 1 (CRABP1) is a prognostic marker for adenocarcinoma and clear cell carcinoma that exhibits chemo-resistance. It is a is a modulator of retinoic acid and plays an important role in retinoic acid-mediated differentiation and proliferation processes. CRABP1 also functions as a tumor-suppressor in esophageal epithelium and its epigenetic silencing may play a pivotal role during esophageal carcinogenesis.
Physical form
Solution in phosphate buffered saline containing 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
M W Kelley et al.
Development (Cambridge, England), 119(4), 1041-1053 (1993-12-01)
The mammalian organ of Corti has one of the most highly ordered patterns of cells in any vertebrate sensory epithelium. A single row of inner hair cells and three or four rows of outer hair cells extend along its length.
Sung Wook Park et al.
The Journal of endocrinology, 236(3), 151-165 (2018-01-27)
Excessive and/or persistent activation of calcium-calmodulin protein kinase II (CaMKII) is detrimental in acute and chronic cardiac injury. However, intrinsic regulators of CaMKII activity are poorly understood. We find that cellular retinoic acid-binding protein 1 (CRABP1) directly interacts with CaMKII
Takahito Miyake et al.
Journal of cancer research and clinical oncology, 137(4), 715-722 (2010-06-24)
CRABP1 is a modulator of retinoic acid function. The aim of the present study was to investigate CRABP1 expression and its clinical significance in ovarian carcinoma. Expression of CRABP1 protein was investigated by immunohistochemical analysis in 100 ovarian carcinomas of
K Tanaka et al.
Oncogene, 26(44), 6456-6468 (2007-04-18)
Epigenetic alterations and the resulting inactivation of tumor suppressor genes often contribute to the development of various cancers. To identify novel candidates that may be silenced by aberrant methylation in esophageal squamous-cell carcinoma (ESCC), we analysed ESCC cell lines by
Shawna D Persaud et al.
Cellular signalling, 25(1), 19-25 (2012-09-18)
All-trans retinoic acid (atRA), one of the active ingredients of vitamin A, exerts canonical activities to regulate gene expression mediated by nuclear RA receptors (RARs). AtRA could also elicit certain non-canonical activities including, mostly, rapid activation of extracellular signal regulated
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