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C1988

Cycloheximide

Name: Cycloheximide
Brand: SIGMA

Biotechnology Performance Certified

동의어(들):

3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₅H₂₃NO₄

CAS 번호:

66-81-9

Molecular Weight:

281.35

UNSPSC Code:

51102829

NACRES:

NA.85

PubChem Substance ID:

24892457

EC Number:

200-636-0

Beilstein/REAXYS Number:

88868

MDL number:

MFCD00082346

기술 서비스

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도움 문의

속성

grade

Biotechnology Performance Certified

Quality Level

200

form

powder

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

fungi, yeast

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

Gene Information

human ... FKBP1A(2280), PIN1(5300)

설명

Application

Cycloheximide is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques and activate cumulus-free equine oocytes.

Biochem/physiol Actions

Cycloheximide (CHX) is an antibiotic produced by S. griseus that inhibits protein biosynthesis in eukaryotes. It inactivate transferase II enzyme that is involved in peptide chain elongation. More recent studies revealed that CHX binds the 60S ribosome and specifically prevents the translocation step in elongation.

Mode of Action: Translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for the selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium