C2020

α-Cyano-4-hydroxycinnamic acid

Name: &#945;-Cyano-4-hydroxycinnamic acid
Brand: SIGMA

≥98% (TLC), powder, monocarboxylic acid transport inhibitor

동의어(들):

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

Linear Formula:

HOC₆H₄CH=C(CN)CO₂H

CAS 번호:

28166-41-8

Molecular Weight:

189.17

NACRES:

NA.77

PubChem Substance ID:

24892459

UNSPSC Code:

12352106

EC Number:

248-879-1

MDL number:

MFCD00004204

Beilstein/REAXYS Number:

3271427

주요 문서

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제품 이름

α-Cyano-4-hydroxycinnamic acid, ≥98% (TLC), powder

InChI key

AFVLVVWMAFSXCK-VMPITWQZSA-N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

SMILES string

OC(=O)\C(=C\c1ccc(O)cc1)C#N

assay

≥98% (TLC)

form

powder

color

yellow

Quality Level

300

solubility

H₂O: slightly soluble, methanol: water: soluble, polar organic solvents: soluble

storage temp.

2-8°C

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Application

α-Cyano-4-hydroxycinnamic acid is a useful hydrophobic matrix solution for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Antibiotics, peptide nucleic acids (a new class of DNA mimics), and proteins with masses as high as 66,000 Da have been successfully analyzed by using this as a matrix solution.

α-Cyano-4-hydroxycinnamic acid has been used to block monocarboxylate transporters.

Biochem/physiol Actions

α-Cyano-4-hydroxycinnamic acid acts as a specific inhibitor of monocarboxylic acid transport, including lactate and pyruvate transport. It is also reported to block β-cell apical anion exchange (IC₅₀ of 2.4 mM).

hcodes

H317

pictograms

GHS07

signalword

Warning

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1B

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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문서 라이브러리 방문

Glucose catabolism in African trypanosomes. Evidence that the terminal step is catalyzed by a pyruvate transporter capable of facilitating uptake of toxic analogs.

J P Barnard et al.

The Journal of biological chemistry, 268(5), 3654-3661 (1993-02-15)

The protozoan parasite Trypanosoma brucei derives its metabolic energy exclusively from a unique type of glycolysis in which pyruvate derived from glucose catabolism is released into the host bloodstream. In this study, this terminal metabolic step has been examined in

L-Lactate Promotes Adult Hippocampal Neurogenesis

Lev-Vachnish Y, et al.

Frontiers in Neuroscience, 13 (2019)

Formulation of matrix solutions for use in matrix-assisted laser desorption/ionization of biomolecules.

E T Sze et al.

Journal of the American Society for Mass Spectrometry, 9(2), 166-174 (1998-07-29)

We report a simple method for converting solid matrices into useful matrix solutions for matrix-assisted laser desorption/ionization (MALDI). This method is based on the dissolution of the solid matrix in a liquid support of low volatility such as glycerol. An

Transport characteristics of the apical anion exchanger of rabbit cortical collecting duct beta-cells.

C Emmons

The American journal of physiology, 276(4 Pt 2), F635-F643 (1999-04-13)

To functionally characterize transport properties of the apical anion exchanger of rabbit beta-intercalated cells, the mean change in anion exchange activity, dpHi/dt (where pHi is intracellular pH), was measured in response to lumen Cl- replacement with gluconate in perfused cortical

Quantitative analysis of antibiotics by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Y C Ling et al.

Rapid communications in mass spectrometry : RCM, 12(6), 317-327 (1998-04-16)

Comparative studies of the matrix-assisted laser desorption/ionization (MALDI) of 30 antibiotics were made using alpha-cyano-4-hydroxycinnamic acid (HCCA), 2,5-dihydroxybenzoic acid (DHB), 5,10,15,20-tetrakis(4-hydroxyphenyl)-21H,23H-porphyrin and meso-tetra(N-methyl-4-pyridyl)porphyrin matrices. Most antibiotics generated intense protonated molecules in HCCA and DHB matrices, and sodium or potassium adduct

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α-Cyano-4-hydroxycinnamic acid

≥98% (TLC), powder, monocarboxylic acid transport inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI key

InChI

SMILES string

assay

form

color

Quality Level

solubility

storage temp.

관련 카테고리

설명

Application

Biochem/physiol Actions

안전성 정보

hcodes

pictograms

signalword

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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