C3956

Anti-c-Myc antibody produced in rabbit

Name: Anti-c-Myc antibody produced in rabbit
Brand: SIGMA

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

동의어(들):

Myc Tag Polyclonal Antibody, c-Myc Antibody

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제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:

12352203

NACRES:

NA.56

MDL number:

MFCD00239651

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, ICC, IF, IP, WB

Citations:

370

주요 문서

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

concentration

~0.5 mg/mL

technique(s)

immunocytochemistry: 5-10 μg/mL, immunoprecipitation (IP): 1-2 μg using immunoprecipitates a c-Myc fusion protein from transfected mammalian cell lysates or bacterial extracts, indirect immunofluorescence: 5-10 μg/mL using detects c-Myc fusion proteins in methanol-acetone fixed transiently transfected cells, microarray: suitable, western blot: 0.5-1 μg/mL using detects c-Myc fusion proteins in cell extracts from transfected cultures as well as bacterial lysates.

UniProt accession no.

P01106

storage temp.

−20°C

Quality Level

200

Gene Information

human ... MYC(4609)

General description

Anti-c-Myc antibody is used for the detection of the c-Myc tag sequence on c-Myc tagged fusion proteins.This polyclonal antibody is produced in rabbit and recognizes the c-Myc sequence at the N-terminus and C-terminus. C3956 is an Affinity purified antibody, increasing sensitivity in most applications.

MYC (MYC proto-oncogene) is a transcriptional factor and oncoprotein. It is located on chromosome 8q24. c-Myc gene codes for basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor.

Immunogen

peptide corresponding amino acids 408-425 of the human c-myc proto-oncogene, conjugated to maleimide-activated KLH through a C-terminal added cysteine residue.

Application

Anti-c-Myc antibody has been used in western blotting and immunofluorescence.

Antibody is recommended for use in immunoblotting, immunoprecipitation and immunofluorescence.
.

Biochem/physiol Actions

MYC (MYC proto-oncogene) may be essential for cancer initiation, promotion and therapy resistance. Overexpression of MYC in DLBCL (diffuse large B-cell lymphoma) results in poor outcome and invasive treatment when medicated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). The cellular myelocytomatosis (c-myc) oncogene plays a major role in cellular proliferation, differentiation and apoptosis. It acts as transcriptional regulator of gene expression.

N-terminal or C-terminal c-Myc (Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu) tagged fusion proteins.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

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저장 등급

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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문서 라이브러리 방문

Functional characterization of the Plasmodium falciparum and P. berghei homologues of macrophage migration inhibitory factor.

Kevin D Augustijn et al.

Infection and immunity, 75(3), 1116-1128 (2006-12-13)

Macrophage migration inhibitory factor (MIF) is a mammalian cytokine that participates in innate and adaptive immune responses. Homologues of mammalian MIF have been discovered in parasite species infecting mammalian hosts (nematodes and malaria parasites), which suggests that the parasites express

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein.

Sarkar S, et al.

The Journal of Biological Chemistry, 282(8), 5641-5652 (2007)

Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network.

Daftuar L, et al.

PLoS ONE, 8(7), e68667-e68667 (2013)

The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1.

von Einem B, et al.

Experimental Neurology, 225(1), 85-93 (2010)

Cysteine-string protein isoform beta (Cspβ) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal β-cells.

Boal F, et al.

Biochimica et Biophysica Acta, 1773(2), 109-119 (2007)

모든 관련된 서류 보기

Anti-c-Myc antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

biological source

conjugate

antibody form

antibody product type

clone

form

species reactivity

concentration

technique(s)

UniProt accession no.

storage temp.

Quality Level

Gene Information

설명

General description

Immunogen

Application

Biochem/physiol Actions

Physical form

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

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