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C4116

Cyclopamine hydrate

Name: Cyclopamine hydrate
Brand: SIGMA

≥98% (HPLC), solid, Hedgehog signaling pathway inhibitor

동의어(들):

11-deoxojervine hydrate

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₇H₄₁NO₂ · xH₂O

CAS 번호:

1217465-07-0

Molecular Weight:

411.62 (anhydrous basis)

UNSPSC Code:

12352116

PubChem Substance ID:

24724439

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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속성

제품 이름

Cyclopamine hydrate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble ≥5 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

O.C[C@@H]1CN[C@H]2[C@@H](C)[C@@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)O[C@@H]2C1

InChI

1S/C27H41NO2.H2O/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2;/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3;1H2/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-;/m0./s1

InChI key

KDAGJRDPNXDDSB-HBYCUIHISA-N

Gene Information

human ... EBP(10682)

설명

General description

Cyclopamine is a steroidal alkaloid, extracted from Veratrum californicum. It prevents tumor cell growth and invasiveness in vitro and in vivo.

Application

Cyclopamine hydrate has been used:

as a sonic hedgehog (Shh) inhibitor in various experiments
to explore the effects of stress stimulation on the proliferation and differentiation of fibrochondrocytes
to study its influence on ocular vessel patterning

Biochem/physiol Actions

Cyclopamine is a Hedgehog signaling pathway inhibitor; inhibits the growth of medulloblastoma cells.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.