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C6643

Clofibrate

Name: Clofibrate
Brand: SIGMA

liquid

동의어(들):

2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester, Ethyl 2-(4-chlorophenoxy)-2-methylpropionate, Ethyl 2-(4-chlorophenoxy)isobutyrate

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₂H₁₅ClO₃

CAS 번호:

637-07-0

Molecular Weight:

242.70

UNSPSC Code:

12352200

NACRES:

NA.77

PubChem Substance ID:

24278085

EC Number:

211-277-4

Beilstein/REAXYS Number:

1913459

MDL number:

MFCD00000615

Form:

liquid

Quality level:

200

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속성

form

liquid

Quality Level

200

color

clear colorless

density

1.14 g/mL at 25 °C (lit.)

originator

Wyeth

storage temp.

2-8°C

SMILES string

CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1

InChI

1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

InChI key

KNHUKKLJHYUCFP-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465)
mouse ... Ppara(19013)

설명

Application

Clofibrate has been used:

as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection
as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells
as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes

Biochem/physiol Actions

Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist. It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.