C8035
Anti-Aggrecan Antibody
mouse monoclonal, CS-56
동의어(들):
Chondroitin Sulfate Antibody, Chondroitin Sulfate Antibody - Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse, Cs56 Antibody
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
CS-56, monoclonal
Application:
indirect immunofluorescence
microarray
microarray
Species reactivity:
chicken, bovine, mouse, human, pig, rabbit, rat
Citations:
168
Technique(s):
indirect immunofluorescence: 1:200 using bovine mammary gland epithelial (BMGE) cells
microarray: suitable
microarray: suitable
Uniprot accession no.:
제품 이름
Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse, clone CS-56, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
CS-56, monoclonal
species reactivity
chicken, bovine, mouse, human, pig, rabbit, rat
technique(s)
indirect immunofluorescence: 1:200 using bovine mammary gland epithelial (BMGE) cells
microarray: suitable
isotype
IgM
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ACAN(176)
mouse ... Acan(11595)
rat ... Acan(58968)
Application
Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse was used:
- in immunohistochemistry as primary antibody to study of spinal cords and brain cryosections.
- in ELISA and western blot for purification of soluble forms of myelin-associated glycoprotein (MAG) and neural cell adhesion molecule (N-CAM).
- in flow cytometry studies.
- as primary antisera in a study of TGF-β regulation.
Biochem/physiol Actions
Chondroitin sulfate is involved in tumor invasion and also plays a vital role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. In Chondroitin sulfate proteoglycan (CSPG), proteoglycan part is involved in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. Chondroitin sulfate is used in osteoarthritis treatment. Upregulation of chondroitin sulfate proteoglycans is observed after neuronal injury. It possess the ability to inhibit axonal regeneration.
The antibody has been reported to be specific for the glycosaminoglycan (GAG) portion of native chondroitin sulfate proteoglycan (CSPG). The antibody reacts specifically with chondroitin sulfate types A and C but not with type B (dermatan sulfate), and may be used for localization of chondroitin sulfate in tissues and cultured fibroblasts.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Chondroitin sulfate is a linear polysaccharide composed of alternating disaccharide glucuronic acid and N-acetylgalactosamine. It contains proteoglycan (PG) of the extracellular matrix (ECM). Monoclonal Anti-Chondroitin Sulfate (mouse IgM isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
This product can be found as purified product that was produced using cell culture hybridoma (SAB4200696)
This product can be found as purified product that was produced using cell culture hybridoma (SAB4200696)
Immunogen
Ventral membranes of chicken gizzard fibroblasts
Other Notes
This product can be found as purified product that was produced using cell culture hybridoma product.
SAB4200696 Anti-Chondroitin Sulfate antibody, Mouse monoclonal
clone CS-56, purified from hybridoma cell culture
SAB4200696 Anti-Chondroitin Sulfate antibody, Mouse monoclonal
clone CS-56, purified from hybridoma cell culture
Preparation Note
For continuous use, store at 2-8 °C for up to one month.
For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
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저장 등급
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Effect of the counterion behavior on the frictional?compressive properties of chondroitin sulfate solutions
Polymer, 50(7), 1805-1813 (2009)
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.
Clegg D O, et al.
The New England Journal of Medicine, 354(8) (2006)
M Sobue et al.
Stain technology, 64(1), 43-47 (1989-01-01)
Dermatan sulfate proteoglycan chains were detected in tissue sections treated with chondroitin B-lyase (0.01 units/ml) in 20 mM Tris-HCl (pH 8.0) for 1 hr, followed by staining with antibody 9A2 specific for unsaturated uronic acid coupled to N-acetylgalactosamine-4 sulfate. In
Charlotte Rolny et al.
The Journal of biological chemistry, 277(22), 19315-19321 (2002-03-26)
Platelet-derived growth factor (PDGF) induces mitogenic and migratory responses in a wide variety of cells, by activating specific receptor tyrosine kinases denoted the PDGF alpha- and beta-receptors. Different PDGF isoforms bind in a distinct manner to glycosaminoglycans, particularly heparan sulfate.
PTPσ is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration.
Shen Y, et al.
Science, 326(5952) (2009)
문서
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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