C9377

Chenodeoxycholic acid

Name: Chenodeoxycholic acid
Brand: SIGMA

동의어(들):

3α,7α-Dihydroxy-5β-cholanic acid, 5β-Cholanic acid-3α,7α-diol, Chenodiol

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₄H₄₀O₄

CAS 번호:

474-25-9

Molecular Weight:

392.57

UNSPSC Code:

12352106

NACRES:

NA.25

PubChem Substance ID:

24893153

EC Number:

207-481-8

Beilstein/REAXYS Number:

3219887

MDL number:

MFCD00064142

주요 문서

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InChI key

RUDATBOHQWOJDD-BSWAIDMHSA-N

InChI

1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

description

anionic

form

powder

mol wt

392.57 g/mol

technique(s)

protein quantification: suitable

CMC

(3), 3

mp

165-167 °C (lit.)

functional group

carboxylic acid

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... CYP1A2(1544), NR1H4(9971)

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Application

Chenodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (CTX). It has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies.

Biochem/physiol Actions

Bile Acid

General description

Chenodeoxycholic acid is a bile acid synthesized in the liver from cholesterol.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

저장 등급

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids.

A Stiehl et al.

Gastroenterology, 98(2), 424-428 (1990-02-01)

The effects of ursodeoxycholic acid and chenodeoxycholic acid on the small-intestinal absorption of endogenous bile acids were studied in patients with ileostomies who served as a model to investigate small-intestinal absorption in humans. In the control period, the eight patients

Gallstone dissolution in man using chenodeoxycholic acid

Bell, G., et al.

Lancet, 300, 1213-1213 null

A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits.

M O Osman et al.

Gut, 43(2), 232-239 (1999-04-06)

Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis. To define the role of IL-8 in acute pancreatitis by neutralising its effects with a

Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5.

Wei Zhou et al.

Journal of biomolecular screening, 15(5), 488-497 (2010-05-08)

Dietary long-chain fatty acid (LCFA) uptake across cell membranes is mediated principally by fatty acid transport proteins (FATPs). Six subtypes of this transporter are differentially expressed throughout the human and rodent body. To facilitate drugs discovery against FATP subtypes, the

Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.

H Reyes et al.

Annals of medicine, 32(2), 94-106 (2000-04-15)

The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) can be related to abnormalities in the metabolism and disposition of sex hormones and/or bile acids, determined by a genetic predisposition interacting with environmental factors. The total amount of oestrogens and progesterone

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프로토콜

HPLC Separation of Bile Acids with Ascentis Express C18

Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.

Chenodeoxycholic acid

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

InChI key

InChI

SMILES string

description

form

mol wt

technique(s)

CMC

mp

functional group

shipped in

storage temp.

Quality Level

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

General description

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

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