C9758
L-Canavanine sulfate salt
plant seeds (Jack bean ), ≥99% (TLC), iNOS inhibitor, powder
동의어(들):
L-α-Amino-γ-(guanidinooxy)butyric acid sulfate salt
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C5H12N4O3 · H2SO4
CAS 번호:
Molecular Weight:
274.25
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
218-728-4
MDL number:
Beilstein/REAXYS Number:
6121291
제품 이름
L-Canavanine sulfate salt, ≥99% (TLC), powder
biological source
plant seeds (Jack bean )
Quality Level
assay
≥99% (TLC)
form
powder
color
white
mp
160-165 °C (dec.)
solubility
H2O: 100 mg/mL
storage temp.
2-8°C
SMILES string
OS(O)(=O)=O.N[C@@H](CCONC(N)=N)C(O)=O
InChI
1S/C5H12N4O3.H2O4S/c6-3(4(10)11)1-2-12-9-5(7)8;1-5(2,3)4/h3H,1-2,6H2,(H,10,11)(H4,7,8,9);(H2,1,2,3,4)/t3-;/m0./s1
InChI key
MVIPJKVMOKFIEV-DFWYDOINSA-N
Gene Information
human ... NOS2(4843)
관련 카테고리
General description
Canavanine is a homolog of arginine and a non-protein amino acid. It is present in plants like alfalfa, cloves, beans onions and sprouts. Canavanine is synthesized from L-canavaninosuccinic acid and the biosynthetic pathway was first elucidated in jack bean plant.
Application
Canavanine sulfate salt has been used:
- as a translation inhibitor in yeast translation studies
- as a component of synthetic complete (SC) drop-out medium for screening yeast
- for screening Saccharomyces cerevisiae in canavanine mutation frequency assay
Biochem/physiol Actions
Canavanine is a naturally occurring L-amino acid that competes and interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). It acts as a substrate for arginyl tRNA and is incorporated during protein synthesis leading to aberrant canavanyl proteins. Supplementation with canavanine worsens the alfalfa induced Systemic lupus erythematosus (SLE) like syndrome and its incorporation with endosome and proteasome disrupts the antigen processing.
Naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS).
Naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes; selective inhibitor of inducible nitric oxide synthase (iNOS).
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Kellyn M Hoffert et al.
Genetics, 213(1), 97-112 (2019-07-20)
Maintenance of genome integrity is a crucial cellular focus that involves a wide variety of proteins functioning in multiple processes. Defects in many different pathways can result in genome instability, a hallmark of cancer. Utilizing a diploid Saccharomyces cerevisiae model
Toshiya Ogata et al.
Cell biology international, 40(1), 100-106 (2015-10-29)
A mitochondrial superoxide dismutase (SOD2) is the first line of antioxidant defense against mitochondrial superoxide. Even though the involvement of SOD2 in lifespan has been studied extensively in several organisms, characterization of the aging process has not been performed for
L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin-1 concentrations in dogs with endotoxic shock
Mitaka C, et al.
Journal of Critical Care, 16(1), 17-23 (2001)
Systematic gene-to-phenotype arrays: a high-throughput technique for molecular phenotyping
Jaeger PA, et al.
Molecular Cell, 69(2), 321-333 (2018)
Cyanamide is biosynthesized from l-canavanine in plants
Kamo T, et al.
Scientific reports, 5, 10527-10527 (2015)
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