D0540
DNQX
≥98% (TLC), kainate, quisqualate (non-NMDA) glutamate receptor antagonist, powder
동의어(들):
6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C8H4N4O6
CAS 번호:
Molecular Weight:
252.14
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
DNQX, ≥98% (TLC)
SMILES string
[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O
InChI
1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
InChI key
RWVIMCIPOAXUDG-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
Quality Level
Gene Information
human ... GRIA1(2890), GRIA2(2891), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)
mouse ... Gria1(14799)
rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)
관련 카테고리
Application
DNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.
Biochem/physiol Actions
A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.
DNQX is a quinoxaline derivative.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
J Waider et al.
Translational psychiatry, 7(10), e1246-e1246 (2017-10-04)
Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice.
Differential Desensitization Observed at Multiple Effectors of Somatic mu-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity
Fox PD and Hentges ST
The Journal of Neuroscience, 37(36), 8667-8677 (2017)
Chuanqiang Zhang et al.
BMC biology, 17(1), 95-95 (2019-11-30)
Optogenetic silencing techniques have expanded the causal understanding of the functions of diverse neuronal cell types in both the healthy and diseased brain. A widely used inhibitory optogenetic actuator is eNpHR3.0, an improved version of the light-driven chloride pump halorhodopsin
Rei Yamada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3927-3938 (2013-03-01)
Neurons in the nucleus laminaris (NL) of birds detect the coincidence of binaural excitatory inputs from the nucleus magnocellularis (NM) on both sides and process the interaural time differences (ITDs) for sound localization. Sustained inhibition from the superior olivary nucleus
Focal activation of neuronal circuits induced by microstimulation in the visual cortex
Tanaka Y, et al.
Journal of Neural Engineering, 16(3), 036007-036007 (2019)
문서
DISCOVER Bioactive Small Molecules for Neuroscience
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