D5412
2′-Deoxyuridine
≥98.5%, synthetic (organic), powder
동의어(들):
1-(2-Deoxy-β-D-ribofuranosyl)uracil, Uracil deoxyriboside
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C9H12N2O5
CAS 번호:
Molecular Weight:
228.20
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
213-455-7
MDL number:
Beilstein/REAXYS Number:
24433
Assay:
≥98.5%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
제품 이름
2′-Deoxyuridine, ≥98.5%
biological source
synthetic (organic)
Quality Level
assay
≥98.5%
form
powder
impurities
Thymidine, free
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O
InChI
1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1
InChI key
MXHRCPNRJAMMIM-SHYZEUOFSA-N
Gene Information
mouse ... Slc29a1(63959)
Application
2′-Deoxyuridine has been used as a:
- precursor of [3H]thymidine triphosphate (TTP) in place of thymidine to avoid a potential thymidine block in relative proliferation assays
- nucleoside supplement for cell cycle synchronization and DNA replication inhibition
- mitotic inhibitor in culture media to minimize the proliferation of glial cells
Biochem/physiol Actions
2′-Deoxyuridine (dU) is frequently halogenated to create thymidine analogs useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2′-deoxyuridines used as labeling substrates include chloro-2′-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogs of 2′-deoxyuridine include 5-ethynyl-2′-deoxyuridine (DdU) and 5-hydroxymethyl-2′-deoxyuridine (HmdU).
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yang Yang et al.
Cancer letters, 453, 170-183 (2019-04-08)
Overexpression of NQO1 is associated with poor prognosis in human cancers including lung, stomach, colon, cervical, and pancreatic cancers. However, the molecular mechanisms underlying the protumorigenic capacities of NQO1 have not been fully elucidated. Here, we investigated this question and
Quan-Liang Jian et al.
PeerJ, 6, e5739-e5739 (2018-10-09)
Both age and intensive exercise are generally considered critical risk factors for osteoarthritis. In this work, we intend to establish zebrafish models to assess the role of these two factors on cartilage homeostasis. We designed a swimming device for zebrafish
Hiroyuki Yamakoshi et al.
Journal of the American Chemical Society, 134(51), 20681-20689 (2012-12-04)
Alkyne has a unique Raman band that does not overlap with Raman scattering from any endogenous molecule in live cells. Here, we show that alkyne-tag Raman imaging (ATRI) is a promising approach for visualizing nonimmobilized small molecules in live cells.
Hongxiu Ning et al.
Cytotherapy, 15(1), 57-63 (2012-12-25)
Thymidine analog 5-ethynyl-2-deoxyuridine (EdU) has recently been used for tracking mesenchymal stem cells (MSCs). In the present study, we tested whether EdU was cytotoxic and whether it interfered with differentiation, cytokine secretion and migration of MSCs. EdU labeling was performed
Shao-yu Wu et al.
Nucleic acids research, 41(8), 4650-4659 (2013-03-02)
Therapeutic small interfering RNAs (siRNAs) are composed of chemically modified nucleotides, which enhance RNA stability and increase affinity in Watson-Crick base pairing. However, the precise fate of such modified nucleotides once the siRNA is degraded within the cell is unknown.
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