D5439
2,3-Dimethoxy-1,4-naphthoquinone
≥99%, solid
동의어(들):
DMNQ
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C12H10O4
CAS 번호:
Molecular Weight:
218.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C12H10O4/c1-15-11-9(13)7-5-3-4-6-8(7)10(14)12(11)16-2/h3-6H,1-2H3
SMILES string
COC1=C(OC)C(=O)c2ccccc2C1=O
InChI key
ZEGDFCCYTFPECB-UHFFFAOYSA-N
assay
≥99%
form
solid
storage temp.
−20°C
Quality Level
Application
2,3-Dimethoxy-1,4-naphthoquinone has been used to investigate the effects of ethanol on podocyte apoptosis under hypoxic and hyperoxic conditions.
Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.
Biochem/physiol Actions
2,3-dimethoxy-1,4-naphthoquinone (DMNQ) has the ability to produce H2O2 through redox cycling but fails to conjugate with glutathione (GSH).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Acute ethanol induces apoptosis by stimulating TRPC6 via elevation of superoxide in oxygenated podocytes
Lu X Y, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1853(5), 965-974 (2015)
Anne R Diers et al.
Redox biology, 1, 1-7 (2013-09-12)
Nitric oxide production by the endothelium is required for normal vascular homeostasis; however, in conditions of oxidative stress, interactions of nitric oxide with reactive oxygen species (ROS) are thought to underlie endothelial dysfunction. Beyond canonical nitric oxide signaling pathways, nitric
Tindaro M Giardina et al.
Biochimica et biophysica acta, 1777(2), 118-129 (2007-12-18)
Uncoupling protein-2 (UCP2) is a member of the inner mitochondrial membrane anion-carrier superfamily. Although mRNA for UCP2 is widely expressed, protein expression is detected in only a few cell types, including macrophages. UCP2 functions by an incompletely defined mechanism, to
Richard Eugene Frye et al.
Scientific reports, 7(1), 4478-4478 (2017-07-02)
Mitoplasticity occurs when mitochondria adapt to tolerate stressors. Previously we hypothesized that a subset of lymphoblastoid cell lines (LCLs) from children with autistic disorder (AD) show mitoplasticity (AD-A), presumably due to previous environmental exposures; another subset of AD LCLs demonstrated
Valerie P Wright et al.
The Journal of physiology, 587(Pt 23), 5767-5781 (2009-10-21)
Skeletal muscles produce transient reactive oxygen species (ROS) in response to intense stimulation, disuse atrophy, heat stress, hypoxia, osmotic stress, stretch and cell receptor activation. The physiological significance is not well understood. Protein phosphatases (PPases) are known to be highly
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