D8668
2′-Deoxyadenosine monohydrate
powder, BioReagent, suitable for cell culture
동의어(들):
9-(2-Deoxy-β-D-ribofuranosyl)adenine, Adenine deoxyriboside
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H13N5O3 · H2O
CAS 번호:
Molecular Weight:
269.26
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
213-488-7
Beilstein/REAXYS Number:
91015
MDL number:
Assay:
≥99% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
H2O: soluble 25 mg/mL, clear to slightly hazy, colorless to faintly yellow
Storage temp.:
2-8°C
InChI key
OLXZPDWKRNYJJZ-RRKCRQDMSA-N
InChI
1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1
SMILES string
[H]O[H].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3
biological source
synthetic (organic)
product line
BioReagent
assay
≥99% (HPLC)
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
H2O: soluble 25 mg/mL, clear to slightly hazy, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
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Application
2′-Deoxyadenosine monohydrate has been used as a nucleotide precursor:
- To study the importance of homologous recombination at the interface between replication and mitosis
- To analyze deoxynucleoside-assisted transductions
- To study the effect of increased deoxycytidine on gemcitabine resistance in pancreatic cancer cells
2′-Deoxyadenosine monohydrate has been used for the preparation of deoxyribonucleoside stock solution for the anaerobic culture of Bacillus mojavensis strains including JF-2 and two Bacillus subtilis strains.
Biochem/physiol Actions
Excess 2′-deoxyadenosine gets converted to adenosine triphosphate (dATP), which inhibits ribonucleotide reductase.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Pharmaceutical Chemistry E-Book, 430-430 (2011)
Pharmaceutical Chemistry, International Edition, 430-430 (2011)
Detection and visualization of protein interactions with protein fragment complementation assays.
I Remy et al.
Methods in molecular biology (Clifton, N.J.), 185, 447-459 (2002-01-05)
MUC1 and HIF-1alpha signaling crosstalk induces anabolic glucose metabolism to impart gemcitabine resistance to pancreatic cancer
Shukla S, et al.
Cancer Cell, 32(1), 71-87 (2017)
Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells
Wilhelm T, et al.
Proceedings of the National Academy of Sciences of the USA, 111(2), 763-768 (2014)
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