D8946
DMH1
≥98% (HPLC), powder, BMP inhibitor
동의어(들):
4-[6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C24H20N4O
CAS 번호:
Molecular Weight:
380.44
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
DMH1, ≥98% (HPLC)
SMILES string
CC(C)OC(C=C1)=CC=C1C(C=N2)=CN3C2=C(C4=CC=NC5=C4C=CC=C5)C=N3
InChI key
JMIFGARJSWXZSH-UHFFFAOYSA-N
InChI
1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
light yellow to orange
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
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관련 카테고리
General description
DMH1 stimulates neurogenesis of human-induced pluripotent stem cells (hiPSCs) and suppresses the growth and metastasis of lung cancer. It blocks cellular autophagy responses.
Application
DMH1 has been used for bone morphogenetic protein (BMP) inhibition.
Biochem/physiol Actions
DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor.
DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH1 is a dorsomorphin analogue that exclusively targets the BMP but not the VEGF pathway.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Silvia Colucci et al.
Blood, 130(19), 2111-2120 (2017-09-03)
The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin FKBP12. FKBP12 interacts with BMP
DMH1 (4-[6-(4-isopropoxyphenyl) pyrazolo [1, 5-a] pyrimidin-3-yl] quinoline) inhibits chemotherapeutic drug-induced autophagy
Sheng Y, et al.
Acta Pharmaceutica Sinica. B, 5(4), 330-336 (2015)
An organizing role for the TGF-β signaling pathway in axes formation of the annelid Capitella teleta
Lanza AR, et al.
Developmental Biology, 435(1), 26-40 (2018)
Mylah Villacorte et al.
Development (Cambridge, England), 143(11), 1958-1970 (2016-04-14)
Thyroid follicles, the functional units of the thyroid gland, are delineated by a monolayer of thyrocytes resting on a continuous basement membrane. The developmental mechanisms of folliculogenesis, whereby follicles are formed by the reorganization of a non-structured mass of non-polarized
BMP signaling is required for nkx2. 3-positive pharyngeal pouch progenitor specification in zebrafish
Li Linwei, et al.
PLoS Genetics, 15(2), e1007996-e1007996 (2019)
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