D9286
Paraoxon-ethyl
≥90%, oil
동의어(들):
O,O-Diethyl O-(4-nitrophenyl) phosphate, Diethyl p-nitrophenyl phosphate, Paraoxon, Paraoxon-ethyl
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크기 선택
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제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
O2NC6H4OP(O)(OC2H5)2
CAS 번호:
Molecular Weight:
275.20
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
206-221-0
Beilstein/REAXYS Number:
1915526
MDL number:
Quality Level
assay
≥90%
form
oil
color
yellow
refractive index
n20/D 1.51 (lit.)
density
1.274 g/mL at 25 °C (lit.)
storage temp.
2-8°C
SMILES string
CCOP(=O)(OCC)Oc1ccc(cc1)[N+]([O-])=O
InChI
1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
InChI key
WYMSBXTXOHUIGT-UHFFFAOYSA-N
Gene Information
human ... PON1(5444)
Application
Paraoxon-ethyl has been used as a substrate in paraoxonase (PON) activity assay. It has also been used as a lipase inhibitor to study the effects of anacetrapib on homotypic transfer from high density lipoprotein L3 (HDL3) to HDL2 in vivo.
Biochem/physiol Actions
Potent irreversible acetylcholinesterase inhibitor
Physical form
Oily liquid
Disclaimer
air sensitive: handle under argon
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Altered lipoproteins in patients with systemic lupus erythematosus are associated with augmented oxidative stress: a potential role in atherosclerosis
Park JK, et al.
Arthritis Research & Therapy, 18(1), 306-306 (2016)
Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution
Woudberg NJ, et al.
Lipids in Health and Disease, 15(1), 92-92 (2016)
Ronit Shiri-Sverdlov et al.
Journal of hepatology, 44(4), 732-741 (2006-02-10)
The molecular mechanisms leading to Non-Alcoholic Steatohepatitis (NASH) are not fully understood. In mice, NASH can be inhibited by fenofibrate, a synthetic agonist for the nuclear receptor peroxisome proliferator activated receptor alpha, which regulates hepatic triglyceride metabolism. This study aimed