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F1293

Finasteride

Name: Finasteride
Brand: SIGMA

≥98% (HPLC), Selective 5α-reductase inhibitor, powder

동의어(들):

N-(2-methyl-2-propyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide, N-tert-Butyl-3-oxo-4-aza-5α-androst-1-en-17β-carboxamide, MK-906

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₃H₃₆N₂O₂

CAS 번호:

98319-26-7

Molecular Weight:

372.54

UNSPSC Code:

41116107

PubChem Substance ID:

24724479

NACRES:

NA.77

MDL number:

MFCD00869737

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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속성

제품 이름

Finasteride, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: soluble >20 mg/mL

storage temp.

room temp

SMILES string

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2

InChI

1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1

InChI key

DBEPLOCGEIEOCV-WSBQPABSSA-N

Gene Information

human ... HSD3B1(3283), SRD5A1(6715), SRD5A2(6716)
rat ... Hsd3b1(360348), Srd5a1(24950), Srd5a2(64677)

설명

Application

Finasteride has been used:

as a component of L-15 media to investigate the effects of finasteride exposure on brain, liver and testis tissues
in culture medium to treat tumor cells in vitro
as a positive control to treat benign prostatic hyperplasia (BPH)
to examine its effect on structural and molecular biology on the ventral prostate of senile mice

Biochem/physiol Actions

Selective 5α-reductase inhibitor; antiandrogen.

Finasteride can reduce serum and scalp dihydrotestosterone (DHT) by preventing the transformation of testosterone to DHT. It is usually used to manage benign prostate hyperplasia and pattern hair loss in male. Finasteride possesses androgen-distracting properties.