F6889
Famotidine
histamine receptor antagonist
동의어(들):
N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C8H15N7O2S3
CAS 번호:
Molecular Weight:
337.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Quality level:
제품 이름
Famotidine,
Quality Level
originator
Johnson & Johnson
SMILES string
N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1
InChI
1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
InChI key
XUFQPHANEAPEMJ-UHFFFAOYSA-N
Gene Information
human ... HRH2(3274)
Application
Famotidine has been used to test its effect on the human ether-a-go-go-related gene (hERG) binding transfected in HEK293 membrane. It has also been used in polycaprolactone based drug delivery studies.
Biochem/physiol Actions
Famotidine is not effective on muscarinic and nicotinic receptors. It competitively inhibits the secretion of gastric acid and elicits mucosal injury protection.
H2 histamine receptor antagonist; anti-ulcer agent
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs
Taha AS, et al.
The New England Journal of Medicine, 334(22), 1435-1439 (1996)
Makoto Anraku et al.
International journal of pharmaceutics, 487(1-2), 142-147 (2015-04-18)
An intermolecular complex formed from a 1:1 weight ratio of chitosan (CS, molecular weight 30 kDa) and sulfobutyl ether β-cyclodextrin (SBE-β-CyD, degree of substitution 7) was less soluble than either of the original components. The release of famotidine from tablets
Polycaprolactone thin-film drug delivery systems: empirical and predictive models for device design
Schlesinger E, et al.
Materials Science and Engineering, C, 57, 232-239 (2015)