G1660
Galanthamine hydrobromide
From plant (Ungeria victoris), ≥94% (HPLC), Cholinesterase inhibitor, powder
동의어(들):
Galantamine hydrobromide
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C17H21NO3 · HBr
CAS 번호:
Molecular Weight:
368.27
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.32
EC Number:
217-780-5
MDL number:
제품 이름
Galanthamine hydrobromide from Lycoris sp., ≥94% (HPLC)
biological source
plant (Ungeria victoris)
Quality Level
assay
≥94% (HPLC)
form
powder
mp
270 °C
solubility
DMSO: soluble 10 mg/mL, clear, colorless, water: soluble 20 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
Br[H].COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24
InChI
1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
InChI key
QORVDGQLPPAFRS-XPSHAMGMSA-N
Gene Information
human ... ACHE(43)
General description
Galanthamine hydrobromide is a derivative of galanthamine, which is an anticholinestrase alkaloid derived from genus Lycoris (Amaryllidaceae) or snowdrop. This compound is used for the treatment of Alzheimer′s disease (AD).
Application
Galanthamine hydrobromide from Lycoris sp. has been used-
- as an AChE (acetylcholinesterase) inhibitor and positive control in acetylcholinesterase assay performed to determine the activity of AChE
- as a positive control in the screening of AChE inhibitors
- as a positive control in AChE inhibitory assay performed to determine the AChE-inhibitory activities of pyrithione and related sulfur-containing pyridine N-oxides
Biochem/physiol Actions
Cholinesterase inhibitor; reverses scopolamine-induced amnesia; antimyasthenic.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Sony Pandey et al.
Microbial cell factories, 13(1), 24-24 (2014-02-18)
Acetylcholinesterase (AChE) inhibitors or anticholinesterases reduce the activity of enzyme acetylcholinesterase that degrades the neurotransmitter acetylcholine in the brain. The inhibitors have a significant pharmacological role in neurodegenerative diseases like Alzheimer's and Parkinson's etc. Although plants have been a significant
Muhammad Ayaz et al.
BMC complementary and alternative medicine, 14, 145-145 (2014-06-03)
We investigated Polygonum hydropiper L. (P. hydropiper) for phenolic contents, antioxidant, anticholinesterase activities, in an attempt to rationalize its use in neurological disorders. Plant crude extract (Ph.Cr), its subsequent fractions: n-hexane (Ph.Hex), chloroform (Ph.Chf), ethyl acetate (Ph.EtAc), n-Butanol (Ph.Bt), aqueous
Bin Hao et al.
Molecules (Basel, Switzerland), 18(3), 2458-2468 (2013-02-27)
Phytochemical investigation of the 80% ethanol extract of the bulbs of Lycoris radiata resulted in the isolation of five new Amaryllidaceae alkaloids: (+)-5,6-dehydrolycorine (1), (+)-3α,6β-diacetyl-bulbispermine (2), (+)-3α-hydroxy-6β-acetyl- bulbispermine (3), (+)-8,9-methylenedioxylhomolycorine-N-oxide (5), and 5,6-dihydro-5- methyl-2-hydroxyphenanthridine (7), together with two known compounds