G3381

Geldanamycin from Streptomyces hygroscopicus

Name: Geldanamycin from <I>Streptomyces hygroscopicus</I>
Brand: SIGMA

from Streptomyces hygroscopicus, ≥98% (HPLC), Nuclear hormone receptor inhibitor, powder

동의어(들):

NSC 122750

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₉H₄₀N₂O₉

CAS 번호:

30562-34-6

Molecular Weight:

560.64

UNSPSC Code:

12352200

PubChem Substance ID:

329799914

NACRES:

NA.77

MDL number:

MFCD00274570

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

300

주요 문서

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제품 이름

Geldanamycin from Streptomyces hygroscopicus, ≥98% (HPLC), powder

sterility

non-sterile

Quality Level

300

assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: soluble

antibiotic activity spectrum

neoplastics

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O

InChI

1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1

InChI key

QTQAWLPCGQOSGP-KSRBKZBZSA-N

General description

Chemical structure: benzenoid

Biochem/physiol Actions

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

저장 등급

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Heat shock protein-90-beta facilitates enterovirus 71 viral particles assembly.

Robert Y L Wang et al.

Virology, 443(2), 236-247 (2013-05-29)

Molecular chaperones are reported to be crucial for virus propagation, but are not yet addressed in Human Enterovirus 71 (EV71). Here we describe the specific association of heat shock protein-90-beta (Hsp90β), but not alpha form (Hsp90α), with EV71 viral particles

Heat shock protein 90-α mediates aldo-keto reductase 1B10 (AKR1B10) protein secretion through secretory lysosomes.

Dixian Luo et al.

The Journal of biological chemistry, 288(51), 36733-36740 (2013-11-13)

Aldo-keto reductase 1B10 (AKR1B10) protein is a new tumor biomarker in humans. Our previous studies have shown that AKR1B10 is secreted through a lysosome-mediated nonclassical pathway, leading to an increase in the serum of breast cancer patients. This study illuminates

Design of novel Geldanamycin analogue hsp90 alpha-inhibitor in silico for breast cancer therapy.

Sailendra Mahanta et al.

Medical hypotheses, 81(3), 463-469 (2013-07-19)

Geldanamycin, which is one of the most potent and effective hsp90 alpha inhibitor until date, is normally used to target breast cancer. Inhibition of hsp90 alpha leads to the degradation of client proteins involved in the initiation and progress of

Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway.

Masaki Nagane et al.

Biochemical and biophysical research communications, 456(1), 541-546 (2014-12-17)

In this study, the involvement of ataxia telangiectasia mutated (ATM) kinase and heat shock protein 90 (HSP90) in endothelial nitric oxide synthase (eNOS) activation was investigated in X-irradiated bovine aortic endothelial cells. The activity of nitric oxide synthase (NOS) and

Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.

Jana Franke et al.

Natural product reports, 30(10), 1299-1323 (2013-08-13)

Covering 2005 to 2013. In this review recent progress in the development of heat shock proteins (Hsp90) in oncogenesis is illuminated. Particular emphasis is put on inhibitors such as geldanamycin and analogues that serve as a natural product show case.

모든 관련된 서류 보기

문서

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Geldanamycin from Streptomyces hygroscopicus

from Streptomyces hygroscopicus, ≥98% (HPLC), Nuclear hormone receptor inhibitor, powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

sterility

Quality Level

assay

form

color

solubility

antibiotic activity spectrum

mode of action

storage temp.

SMILES string

InChI

InChI key

관련 카테고리

설명

General description

Biochem/physiol Actions

Features and Benefits

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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