G6416
GW5074
powder
동의어(들):
3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H8Br2INO2
CAS 번호:
Molecular Weight:
520.94
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
LMXYVLFTZRPNRV-KMKOMSMNSA-N
SMILES string
Oc1c(Br)cc(cc1Br)\C=C2/C(=O)Nc3ccc(I)cc23
InChI
1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
yellow to orange-brown
solubility
DMSO: 5 mg/mL, clear
storage temp.
room temp
Quality Level
Gene Information
human ... RAF1(5894)
Application
GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.
Biochem/physiol Actions
GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.
Other Notes
light sensitive
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Human intestinal epithelial cells respond to beta-glucans via Dectin-1 and Syk
Cohen-Kedar S, et al.
European Journal of Immunology, 44(12), 3729-3740 (2014)
ERK12 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts
Kefaloyianni E, et al.
Cellular Signalling, 18(12), 2238-2251 (2006)
Kaia Mobraten et al.
Lipids in health and disease, 12, 101-101 (2013-07-16)
Omega-3 PUFAs are known to have anti-inflammatory properties, and different mechanisms are involved. GPR120 is a G-protein coupled receptor that has recently received attention because of its anti-inflammatory signalling properties after binding omega-3 PUFAs. However, both omega-3 and omega-6 PUFAs
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism
Chin PC, et al.
Journal of Neurochemistry, 90(3), 595-608 (2004)
The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice
Lei Y, et al.
Respiratory Research, 9(1), 71-71 (2008)
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