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Merck

G9020

Gastrin I human

≥95% (HPLC), powder

동의어(들):

Gastrin I, heptadecapeptide, HG-17, Little gastrin I, human, [18-Pyroglutamic acid]big gastrin I-(18-34)-peptide amide, human, [pGlu18]-Big gastrin I fragment 18-34 amide

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C97H124N20O31S
CAS 번호:
10047-33-3
Molecular Weight:
2098.20
NACRES:
NA.32
PubChem Substance ID:
24895361
UNSPSC Code:
12352200
EC Number:
233-157-0
MDL number:
MFCD00076500

주요 문서

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InChI key

GKDWRERMBNGKCZ-RNXBIMIWSA-N

InChI

1S/C97H124N20O31S/c1-49(2)39-68(114-95(146)71(43-54-46-100-59-18-11-9-16-57(54)59)116-97(148)73-19-12-37-117(73)76(121)48-102-85(136)60-24-30-74(119)104-60)93(144)110-65(29-35-81(130)131)91(142)109-64(28-34-80(128)129)90(141)108-63(27-33-79(126)127)89(140)107-62(26-32-78(124)125)88(139)106-61(25-31-77(122)123)87(138)103-50(3)84(135)113-69(41-52-20-22-55(118)23-21-52)86(137)101-47-75(120)105-70(42-53-45-99-58-17-10-8-15-56(53)58)94(145)111-66(36-38-149-4)92(143)115-72(44-82(132)133)96(147)112-67(83(98)134)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,60-73,99-100,118H,12,19,24-44,47-48H2,1-4H3,(H2,98,134)(H,101,137)(H,102,136)(H,103,138)(H,104,119)(H,105,120)(H,106,139)(H,107,140)(H,108,141)(H,109,142)(H,110,144)(H,111,145)(H,112,147)(H,113,135)(H,114,146)(H,115,143)(H,116,148)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H,132,133)/t50-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-/m0/s1

SMILES string

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H]6CCCN6C(=O)CNC(=O)[C@@H]7CCC(=O)N7)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc8ccccc8)C(N)=O

biological source

human

assay

≥95% (HPLC)

form

powder

mol wt

2098.20

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

concentration

≤100%

technique(s)

protein expression: suitable

solubility

water: 1.00-1.04 mg/mL, clear, colorless

UniProt accession no.

P01350

storage temp.

−20°C

Quality Level

200

Gene Information

human ... GAST(2520)

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General description

Research area: Cell Signaling

The GAST gene is mapped to human chromosome 17q21. Gastrin is a linear peptide. It is a gastrointestinal hormone, produced by G cells in the stomach.

Application

Gastrin I human has been used:
  • to treat AGS stably transfected with gastrin receptor/cholecystokinin receptor 2 (CCK2R) (AGS-GR) cells to study the expression and secretion of clusterin (CLU) in human gastric cancer cells
  • as a component of growth medium for culturing mouse normal esophageal epithelial organoid (mNEEO)
  • as a supplement in basal culture media to use for organoid-like cultures
  • as a molecular weight marker to calibrate superdex® 30 columns.

Biochem/physiol Actions

Gastrin plays a major role in parietal cell function, gastric epithelial cell multiplication, and differentiation. It acts as a modulator in maintaining and organizing gastric mucosa. It is produced in the stomach and stimulates gastric acid secretion. Gastrin is an important growth factor for the gastrointestinal tract. Gastrin binds with high affinity to the cholecystokinin B receptor (CCKBR) that belongs to the family of G-protein coupled receptors. It induces islet differentiation in the pancreas.

Other Notes

Lyophilized from 0.1% TFA in H2O

Legal Information

Superdex is a registered trademark of Cytiva

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
099M4861V
029M4756V
029M4755V
098M4887V
058M4840V

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

A network map of the gastrin signaling pathway.
Yashwanth Subbannayya et al.
Journal of cell communication and signaling, 8(2), 165-170 (2014-03-04)
Physiology of cholangiocytes
Physiology of the Gastrointestinal Tract (2012)
Y Konda et al.
The American journal of physiology, 277(4 Pt 1), G773-G784 (1999-10-12)
Gastrin stimulates the growth of gastric mucosa by increasing mostly its glandular region but is not known to induce the growth of a pit region where its major constituent cells, gastric surface mucous (GSM) cells, turn over rapidly. To investigate
S A Watson et al.
Gut, 45(6), 812-817 (1999-11-24)
Gastrin is a growth factor for established tumours. To investigate the therapeutic effect of antibodies, raised against the Gastrimmune immunogen, which neutralise the glycine extended and carboxy amidated forms of gastrin 17 in two human gastric cancer models. MGLVA1 cells
Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells
Rao S V, et al.
BMC Cancer, 17(1), 68-68 (2017)
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