H2519
Heparinase I from Flavobacterium heparinum
Lyophilized powder stabilized with approx. 25% bovine serum albumin, ≥200 units/mg protein (enzyme + BSA)
동의어(들):
Heparin lyase I, Heparinase
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
CAS 번호:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
≥200 units/mg protein (enzyme + BSA)
conjugate
conjugate (Glucosaminoglycan)
form
lyophilized solid
specific activity
≥200 units/mg protein (enzyme + BSA)
mol wt
42.8 kDa
application(s)
diagnostic assay manufacturing
storage temp.
−20°C
Quality Level
Application
Heparinase I from Flavobacterium heparinum has been used:
- in the digestion of plasma samples
- to study the effect of medium, washing and sonication on the infectivity of Chlamydia pneumonia
- in enzymatic removal of heparan sulfate from the surface of human rhabdomyosarcoma cells
Biochem/physiol Actions
Heparinase I from Flavobacterium heparinum acts by cleaving the α-glycoside linkage at AT III binding site in heparin. This results in small oligosaccharide fragments . Heparinase I neutralizes the protein′s action of anticoagulation. Heparinase I possesses a half-life of 15-18 minutes.
Other Notes
One unit (Sigma unit) will form 0.1 μmole of unsaturated uronic acid per hr at pH 7.5 at 25 °C. One International Unit (I.U.) is equivalent to approx. 600 Sigma units.
View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Avery Davis Bell et al.
Nature, 583(7815), 259-264 (2020-06-05)
Meiosis, although essential for reproduction, is also variable and error-prone: rates of chromosome crossover vary among gametes, between the sexes, and among humans of the same sex, and chromosome missegregation leads to abnormal chromosome numbers (aneuploidy)1-8. To study diverse meiotic
Udayanath Aich et al.
Analytical chemistry, 83(20), 7815-7822 (2011-08-26)
Heparin and the low molecular weight heparins are extensively used as medicinal products to prevent and treat the formation of venous and arterial thrombi. In early 2008, administration of some heparin lots was associated with the advent of severe adverse
Coxsackievirus A16 utilizes cell surface heparan sulfate glycosaminoglycans as its attachment receptor
Zhang X, et al.
Emerging microbes & infections, 6(7), e65-e65 (2017)
Differential expression of plasma microRNA in preeclamptic patients at delivery and 1 year postpartum
Murphy MSQ, et al.
American Journal of Obstetrics and Gynecology, 213(3), 367-e1-367-e1 (2015)
Methodological aspects affecting the infectivity of Chlamydia pneumoniae in cell cultures in vitro
Yan Y, et al.
Journal of Microbiological Methods, 61(1), 127-130 (2005)
문서
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
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