I1637

Ipratropium bromide monohydrate

Name: Ipratropium bromide monohydrate
Brand: SIGMA

≥98% (TLC), powder

동의어(들):

Atropine isopropyl bromide

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₀H₃₀BrNO₃· H₂O

CAS 번호:

66985-17-9

Molecular Weight:

430.38

NACRES:

NA.77

PubChem Substance ID:

24277843

UNSPSC Code:

12352200

EC Number:

244-873-8

MDL number:

MFCD00792907

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

주요 문서

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Quality Level

200

assay

≥98% (TLC)

form

powder

color

white

solubility

H₂O: 10 mg/mL

originator

Boehringer Ingelheim

SMILES string

O.[Br-].CC(C)[N@+]1(C)[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3

InChI

1S/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1/t16-,17+,18+,19?,21?;;

InChI key

KEWHKYJURDBRMN-XSAPEOHZSA-M

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Application

Ipratropium bromide monohydrate has been used for the inhibition of peripheral muscarinic receptors in rats.

Biochem/physiol Actions

Ipratropium bromide monohydrate is a nonselective muscarinic acetylcholine receptor antagonist and a bronchodilator. In nebulized form, it is used for treating asthma and obstructive pulmonary diseases. It acts as a β₂ adrenoreceptor agonist. Ipratropium bromide monohydrate is an anticholinergic agent and competes with acetylcholine. It promotes bronchodilation by stimulating sympathetic pathways.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

N-isopropyl quaternary salt of atropine.

pictograms

GHS07

signalword

Warning

hcodes

H302 + H332,H319

pcodes

P261 - P264 - P271 - P301 + P312 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2

저장 등급

11 - Combustible Solids

wgk

WGK 2

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문서 라이브러리 방문

The pharmacological properties of tiotropium.

P J Barnes

Chest, 117(2 Suppl), 63S-66S (2000-02-16)

Tiotropium is a long-acting anticholinergic drug. Studies with cloned human muscarinic receptors show that tiotropium binds equally well to M(1), M(2), and M(3) receptors. However, it dissociates very slowly from M(1) and M(3) receptors compared with ipratropium, and more rapidly

Ipratropium decreases airway size in dogs by preferential M2 muscarinic receptor blockade in vivo.

H Groeben et al.

Anesthesiology, 85(4), 867-873 (1996-10-01)

Two major groups of drugs are available to prevent bronchoconstriction: beta-agonists and muscarinic blocking agents. Ipratropium is the most commonly used anticholinergic agent to treat chronic obstructive pulmonary disease. The authors studied anti-muscarinic agents to determine if they are as

Bilateral acute angle closure developing due to use of ipratropium bromide and salbutamol.

Kola M, et al.

International Ophthalmology, 38(1), 385-388 (2018)

Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate.

Ogoda M, et al.

Journal of Pharmacological Sciences, 115(3), 374-382 (2011)

For COPD a combination of ipratropium bromide and albuterol sulfate is more effective than albuterol base.

Campbell S

Archives of Internal Medicine, 159(2), 156-160 (1999)

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Ipratropium bromide monohydrate

≥98% (TLC), powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

Quality Level

assay

form

color

solubility

originator

SMILES string

InChI

InChI key

Gene Information

설명

Application

Biochem/physiol Actions

Features and Benefits

Other Notes

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

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