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I7018

3-Isobutyl-1-methylxanthine

Name: 3-Isobutyl-1-methylxanthine
Brand: SIGMA

≥99%, Phosphodiesterase inhibitor

동의어(들):

1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMX

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₀H₁₄N₄O₂

CAS 번호:

28822-58-4

Molecular Weight:

222.24

NACRES:

NA.77

PubChem Substance ID:

24896107

UNSPSC Code:

12352202

EC Number:

249-259-3

MDL number:

MFCD00005584

Beilstein/REAXYS Number:

247859

기술 서비스

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속성

제품 이름

3-Isobutyl-1-methylxanthine, BioUltra, ≥99%

product line

BioUltra

Quality Level

200

assay

≥99%

impurities

<0.005% Phosphorus (P)

ign. residue

<0.1%

mp

200-201 °C (lit.)

solubility

DMSO: soluble 1 M (with gentle warming)

anion traces

sulfate (SO₄^2-): <0.05%

cation traces

Al: <0.0005%, Ca: <0.005%, Cu: <0.0005%, Fe: <0.005%, K: <0.05%, Mg: <0.005%, NH₄⁺: <0.05%, Na: <0.005%, Pb: <0.001%, Zn: <0.0005%

storage temp.

−20°C

SMILES string

CC(C)CN1C(=O)N(C)C(=O)c2[nH]cnc12

InChI

1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)

InChI key

APIXJSLKIYYUKG-UHFFFAOYSA-N

Gene Information

rat ... Adora1(29290), Adora2a(25369)

설명

Application

3-Isobutyl-1-methylxanthine, an inhibitor of adenosine 3′,5′-cyclic monophosphate phosphodiesterase (cAMP PDE), has been used:

for adipogenic differentiation
in tissue culture
3T3-L1 preadipocyte differentiation(

Biochem/physiol Actions

The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.

The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC₅₀: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.

Features and Benefits

Trace element testing by ICP
ICP testing for trace sulfur (as sulfate) and phosphorus (as phosphate) content
Ion chromatography testing for trace ammonium content

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저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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