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I7378

Indomethacin

Name: Indomethacin
Brand: SIGMA

98.0-102.0% (meets EP testing specifications), powder or crystals, COX inhibitor

동의어(들):

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₉H₁₆ClNO₄

CAS 번호:

53-86-1

Molecular Weight:

357.79

NACRES:

NA.77

PubChem Substance ID:

24278173

UNSPSC Code:

12161501

EC Number:

200-186-5

MDL number:

MFCD00057095

Beilstein/REAXYS Number:

497341

Assay:

98.0-102.0% (in accordance with EP), 98.0-102.0%

Form:

powder or crystals

Quality level:

200

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속성

제품 이름

Indomethacin, 98.0-102.0%, meets EP testing specifications

biological source

synthetic

Quality Level

200

agency

meets EP testing specifications

assay

98.0-102.0% (in accordance with EP), 98.0-102.0%

form

powder or crystals

loss

≤0.5% loss on drying

mp

158-162 °C

mode of action

enzyme | inhibits

SMILES string

COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3

InChI

1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

InChI key

CGIGDMFJXJATDK-UHFFFAOYSA-N

Gene Information

human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224)
rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)

설명

General description

Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome. Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis.

Application

Indomethacin has been used:

as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells
as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture
in the inhibition of prostaglandin E2 (PGE2) in T cells

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 1 Oral

저장 등급

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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