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I7379

Imipramine hydrochloride

Name: Imipramine hydrochloride
Brand: SIGMA

≥99% (TLC), powder, selective serotonin reuptake inhibitor

동의어(들):

10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₉H₂₄N₂ · HCl

CAS 번호:

113-52-0

Molecular Weight:

316.87

NACRES:

NA.77

PubChem Substance ID:

24278097

UNSPSC Code:

12352116

EC Number:

204-030-7

MDL number:

MFCD00012669

Assay:

≥99% (TLC)

Form:

powder

Quality level:

200

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제품 이름

Imipramine hydrochloride, ≥99% (TLC)

Quality Level

200

assay

≥99% (TLC)

form

powder

color

white

solubility

H₂O: 50 mg/mL

originator

Novartis

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13

InChI

1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

InChI key

XZZXIYZZBJDEEP-UHFFFAOYSA-N

Gene Information

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General description

Imipramine is a tricyclic antidepressant. It has a half-life of 6 to 20 hours. Imipramine is made up of a tricyclic nucleus, that consists of two phenyl rings and a central cycloheptadien ring.

Application

Imipramine hydrochloride has been used:

as a non- selective serotonin reuptake inhibitor (SSRI) tricyclic anti-depressant (DD-IMI) to treat animals
to investigate its interaction with insulin in aqueous solution
to abolish the ability of internalized lipoproteins to stimulate cholesteryl esterification

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with K_is of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (K_i = 25 μM).

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters; has little effect on the dopamine transporter.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral

저장 등급

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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