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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H15NO4 · H2O
CAS 번호:
Molecular Weight:
231.25
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
제품 이름
Kainic acid monohydrate, ≥98% (HPLC), from Digenea simplex
biological source
Digenea simplex
assay
≥98% (HPLC)
form
powder
color
white
solubility
H2O: >10 mg/mL
storage temp.
2-8°C
SMILES string
O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
InChI
1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
InChI key
FZNZRJRSYLQHLT-SLGZUKMRSA-N
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Application
Kainic acid monohydrate has been used:
- As a convulsant to induce epileptogenesis and epilepsy in mice.
- To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
- To induce seizures in rat model.
- To induce status epilepticus in adult male Wistar rats.
Biochem/physiol Actions
Agonist for kainate class of ionotropic glutamate receptors.
Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.
Ionotropic glutamate receptors form ion channels, and conduct Na+ and K+ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro
Wang Q and Green SH
The Journal of Neuroscience, 31(21), 7938-7949 (2011)
Basic Neurochemistry: Molecular, Cellular and Medical Aspects. (2005)
David P D Woldbye et al.
Brain : a journal of neurology, 133(9), 2778-2788 (2010-08-07)
Gene therapy using recombinant adeno-associated viral vectors overexpressing neuropeptide Y in the hippocampus exerts seizure-suppressant effects in rodent epilepsy models and is currently considered for clinical application in patients with intractable mesial temporal lobe epilepsy. Seizure suppression by neuropeptide Y
Diffusion tensor MRI of axonal plasticity in the rat hippocampus
Laitinen T, et al.
Neuroimage, 51(2), 521-530 (2010)
Carlos G Martinez-Moreno et al.
International journal of molecular sciences, 20(18) (2019-09-13)
In addition to its role as an endocrine messenger, growth hormone (GH) also acts as a neurotrophic factor in the central nervous system (CNS), whose effects are involved in neuroprotection, axonal growth, and synaptogenic modulation. An increasing amount of clinical
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