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L1295

Lamivudine

Name: Lamivudine
Brand: SIGMA

≥98% (HPLC), nRTI inhibitor, powder

동의어(들):

2′,3′-Dideoxy-3′-thiacytidine, 3TC, Epivir, Epivir-HBV, Heptovir, Zeffix

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₈H₁₁N₃O₃S

CAS 번호:

134678-17-4

Molecular Weight:

229.26

UNSPSC Code:

12352200

PubChem Substance ID:

329817388

NACRES:

NA.77

MDL number:

MFCD00869739

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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속성

제품 이름

Lamivudine, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

water: 10 mg/mL, clear

originator

GlaxoSmithKline

storage temp.

room temp

SMILES string

NC1=NC(=O)N(C=C1)[C@@H]2CS[C@H](CO)O2

InChI

1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1

InChI key

JTEGQNOMFQHVDC-NKWVEPMBSA-N

설명

Application

Lamivudine has been used to deplete the Hepatitis B Virus (HBV) covalently closed circular DNA (cccDNA) forms for the preparation of inverse nested PCR.

Biochem/physiol Actions

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS08

signalword

Warning

저장 등급

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

target_organs

Blood

hcodes

H361d,H373,H412

pcodes

P202 - P260 - P273 - P280 - P308 + P313 - P405

Hazard Classifications

Aquatic Chronic 3 - Repr. 2 - STOT RE 2

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