M5005
Manganese(II) chloride tetrahydrate
BioReagent, suitable for insect cell culture
동의어(들):
Manganese chloride hydrate, Manganese chloride tetrahydrate, MnCl2.4H2O
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
MnCl2 · 4H2O
CAS 번호:
Molecular Weight:
197.91
NACRES:
NA.28
PubChem Substance ID:
UNSPSC Code:
12352207
EC Number:
231-869-6
MDL number:
Assay:
≥99% (by AgNO3, titration)
InChI key
CNFDGXZLMLFIJV-UHFFFAOYSA-L
InChI
1S/2ClH.Mn.4H2O/h2*1H;;4*1H2/q;;+2;;;;/p-2
SMILES string
Cl[Mn]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H]
product line
BioReagent
assay
≥99% (by AgNO3, titration)
technique(s)
cell culture | insect: suitable
mp
58 °C (lit.)
Quality Level
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관련 카테고리
Application
Manganese(II) chloride tetrahydrate has been used:
- as trace element in the fungal complete medium
- as a supplement in the culture medium for cochlear organotypic culture
- to determine its in vivo antiviral activity against herpes simplex virus-1 (HSV-1), vesicular stomatitis virus (VSV) and vaccinia virus in mice
Biochem/physiol Actions
Manganese is an essential and one of the abundant metal in the tissues of mammals. It plays a key role in the physiological process like development, neuronal function, immune regulation, reproduction, and antioxidant defences. It functions as a cofactor and regulates the activity of the enzymes like oxido-reductases, isomerases, transferases, ligases, lyases and hydrolases It is involved in the innate immunity against viruses.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Dam. 1 - STOT RE 2
target_organs
Brain
wgk
WGK 2
flash_point_f
does not flash
flash_point_c
does not flash
ppe
dust mask type N95 (US), Eyeshields, Gloves
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting Apoptosis
Ding X, et al.
Toxicology Letters, 310, 51-60 (2019)
manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses.
Wang C, et al.
Immunity, 48(4), 675-687 (2018)
Weilong Wang et al.
Toxicology letters, 279, 77-86 (2017-08-06)
Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including
Agrobacterium-mediated transformation of the filamentous fungus Aspergillus awamori.
Michielse CB, et al.
Nature Protocols, 3(10), 1671-1671 (2008)
Xuerui Ding et al.
Toxicology letters, 310, 51-60 (2019-04-17)
Manganese (Mn) is an essential cofactor for many enzymes and thus plays an important role in normal growth and development. However, persistent exposure to high Mn concentrations can result in deleterious effects on not only the central nervous system but
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