M6517
α,β-Methyleneadenosine 5′-triphosphate lithium salt
≥93% (HPLC), P2 purinoceptor agonist, solid
동의어(들):
AMP-CPP
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C11H18N5O12P3 · xLi+
CAS 번호:
Molecular Weight:
505.21 (free acid basis)
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
α,β-Methyleneadenosine 5′-triphosphate lithium salt, ≥93% (HPLC), solid
Quality Level
assay
≥93% (HPLC)
form
solid
color
white
solubility
H2O: 100 mg/mL
storage temp.
−20°C
SMILES string
[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)CP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
InChI
1S/C11H18N5O12P3.Li/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-29(19,20)4-30(21,22)28-31(23,24)25;/h2-3,5,7-8,11,17-18H,1,4H2,(H,19,20)(H,21,22)(H2,12,13,14)(H2,23,24,25);/q;+1/p-1/t5-,7-,8-,11-;/m1./s1
InChI key
NVHVREPTGDOYIC-YCSZXMBFSA-M
Gene Information
human ... P2RX1(5023)
Application
α,β-Methyleneadenosine 5′-triphosphate lithium salt has been used:
- as P2-purinoreceptor agonist (P2X), to analyse its effects on membrane conductance in the astrocytes of caudal nucleus
- as a P2X receptor agonist, to increase the calcium current in the neurons in satellite cells
- to determine the functional sensitivities of purinergic agonists on P2Y receptors in rat and to determine its effect on developing outer sulcus cells
Biochem/physiol Actions
P2 purinoceptor agonist that is more potent than ATP at the P2X subtype.
Features and Benefits
This compound is featured on the P2 Receptors: P2X Ion Channel Family and P2 Receptors: P2Y G-Protein Family pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Physical form
hygroscopic solid
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Tanumoy Mondol et al.
Nucleic acids research, 47(4), 1977-1986 (2019-01-04)
DNA polymerase delta (Pol δ) is responsible for the elongation and maturation of Okazaki fragments in eukaryotic cells. Proliferating cell nuclear antigen (PCNA) recruits Pol δ to the DNA and serves as a processivity factor. Here, we show that PCNA
G Burnstock et al.
General pharmacology, 16(5), 433-440 (1985-01-01)
It is suggested that the P2-purinoceptor may be separated into two subtypes largely on the basis of the rank order of agonist potency of structural analogues of ATP and also on the activity of antagonists at the P2-purinoceptor: Subtype 1
Catherine A Regni et al.
The EMBO journal, 28(13), 1953-1964 (2009-06-06)
The 39-kDa Escherichia coli enzyme MccB catalyses a remarkable posttranslational modification of the MccA heptapeptide during the biosynthesis of microcin C7 (MccC7), a 'Trojan horse' antibiotic. The approximately 260-residue C-terminal region of MccB is homologous to ubiquitin-like protein (UBL) activating
X Bo et al.
British journal of urology, 76(3), 297-302 (1995-09-01)
To characterize [3H] alpha, beta-methylene adenosine 5'-triphosphate ([3H] alpha, beta-MeATP, a radioligand for P2x-purinoceptors) binding sites in the washed homogenates and membrane preparations of human urinary bladder and, using autoradiography, to localize [3H] alpha, beta-MeATP binding sites in human bladder.
GABA-mediated modulation of ATP-induced intracellular calcium responses in nodose ganglion neurons of the rat
Yokoyama T, et al.
Neuroscience Letters, 584, 168-172 (2015)
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