M7949
Mitomycin C from Streptomyces caespitosus
≥98% (HPLC), γ-irradiated, suitable for cell culture
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H18N4O5
CAS 번호:
Molecular Weight:
334.33
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
200-008-6
Beilstein/REAXYS Number:
7231816
MDL number:
InChI
1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChI key
NWIBSHFKIJFRCO-WUDYKRTCSA-N
SMILES string
[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O
biological source
Streptomyces caespitosus
sterility
γ-irradiated
assay
≥98% (HPLC)
form
powder or crystals
technique(s)
cell culture | mammalian: suitable
color
dark blue
mp
>360 °C
solubility
DMSO: 1.0 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, neoplastics
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
Quality Level
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관련 카테고리
Application
Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.
Biochem/physiol Actions
Mode of Action: This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5′-CpG-3′. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication.
Antimicrobial Spectrum: Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.
Antimicrobial Spectrum: Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.
Disclaimer
Stock solutions should be filter sterilized and stored at 2-8°C in the dark. Solutions at pH 6-9 can be stored at 0-5°C for up to a week, but if a precipitate forms, a fresh solution should be prepared - the precipitated solution has been proven toxic to cells.
Preparation Note
Mitomycin C is soluble in DMSO at 1.0 mg/mL
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 2
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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문서
Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic
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