M8064
Anti-Myosin IIA, non muscle antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
동의어(들):
Anti-BDPLT6, Anti-DFNA17, Anti-EPSTS, Anti-FTNS, Anti-MATINS, Anti-MHA, Anti-NMHC-II-A, Anti-NMMHC-IIA, Anti-NMMHCA
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IF, WB
Citations:
96
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~200 kDa
species reactivity
rat, human, canine
packaging
antibody small pack of 25 μL
technique(s)
indirect immunofluorescence: 1:100 using cultured rat NRK cells, microarray: suitable, western blot: 1:1,000 using whole cell extracts of cultured dog MDCK kidney cells and cultured human Jurkat cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MYH9(4627)
rat ... Myh9(25745)
General description
Myosin heavy chain 9 (MYH9) gene codes for the nonmuscle myosin heavy chain IIA.
Myosin heavy chain 9 is expressed in platelets and the gene encoding it is localized on chromosome 22.
Immunogen
synthetic peptide corresponding to amino acids 1949-1960 of human nonmuscle myosin IIA.
Application
Anti-Myosin IIA, non muscle antibody produced in rabbit has been used in:
- immunofluorescence
- immunohistochemistry
- fixed cell staining/ immunofluorescence staining
- immunoblot
- immunoprecipitation
Biochem/physiol Actions
Nonmuscle myosin II is involved in cell motility and adhesion, cytokinesis, vesicular transport, intracellular force generation and in morphogenesis during development. Its activity is regulated by light chain and possibly heavy chain phosphorylation and by association with proteins such as Mts1. Mutations in the NMHCA gene are found in several syndromes associated with megakaryocyte/platelet/leukocyte disorders. Mutations in the MYH9 gene causes a spectrum of macrothrombocytopenia disorders with neutrophil inclusions, termed as MYH9 disorders.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Nonmuscle myosin-2: mix and match
Heissler SM and Manstein DJ
Cellular and Molecular Life Sciences, 70(1), 1-21 (2013)
C Ling et al.
Genetics and molecular research : GMR, 14(1), 1008-1016 (2015-03-03)
Genetic factors play an important role in type 2 diabetes (T2D) complications. Alteration of cerebrovascular blood flow (CBF) is a direct result of cerebrovascular diseases. However, few studies have reported the role of genetics on CBF in patients with T2D.
Y Chen et al.
Journal of thrombosis and haemostasis : JTH, 11(12), 2163-2175 (2013-10-30)
Mutations in the MYH9 gene cause autosomal dominant MYH9-related diseases (MYH9-RD) that associate macrothrombocytopenia with various other clinical conditions. The mechanisms giving rise to giant platelets remain poorly understood. To study the proplatelet formation (PPF) derived from megakaryocytes (MKs) generated
Philip P Ostrowski et al.
Developmental cell, 50(4), 397-410 (2019-06-25)
Phagocytosis, the engulfment of particulate matter, requires the coordinated polymerization of F-actin; however, the nature and dynamics of the F-actin structures generated during the process are incompletely defined. Using super-resolution microscopy, we observed the formation of podosome-like structures during Fc
Hemostasis and Thrombosis
Hematopathology, 57-105 (2018)
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