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N2001

Neostigmine bromide

≥98% (HPLC and titration), acetylcholinesterase inhibitor, powder

동의어(들):

3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide, Prostigmine

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C12H19BrN2O2
CAS 번호:
114-80-7
Molecular Weight:
303.20
NACRES:
NA.77
PubChem Substance ID:
24277854
UNSPSC Code:
12352200
EC Number:
204-054-8
MDL number:
MFCD00011795
Assay:
≥98% (HPLC and titration)
Form:
powder
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제품 이름

Neostigmine bromide, ≥98% (HPLC and titration), powder

assay

≥98% (HPLC and titration)

form

powder

color

white

mp

175-177 °C (lit.)

solubility

H2O: 1 g/mL, ethanol: soluble

SMILES string

[Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C

InChI

1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1

InChI key

LULNWZDBKTWDGK-UHFFFAOYSA-M

Gene Information

human ... ACHE(43)

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관련 카테고리

Application

Neostigmine bromide has been used as an acetyl cholinesterase (AChE) inhibitor:
  • to control reaction specificity of acetylcholinesterase in coronal organ of Botryllus schlosseri.
  • to study its effects on abnormal contraction of pyloric circular smooth muscle strips (PCSMS).
  • to study its effects on depolarization of bag cell neurons.

Biochem/physiol Actions

Neostigmine bromide is a quaternary amine. It is involved in elongating and boosting the muscarinic and nicotinic effects of acetylcholine by inhibiting cholinesterase activity. It is used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers.
Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier.
Reversible inhibitor of acetylcholinesterase; does not cross the blood-brain barrier.

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

저장 등급

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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시험 성적서(COA)

Lot/Batch Number
108K1592
108K1591
108K1031
097K1421
097K1420

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문서 라이브러리 방문

M Weinstock et al.
The Journal of pharmacology and experimental therapeutics, 218(2), 504-508 (1981-08-01)
The influence of physostigmine was studied on the effect of morphine on the cardiovascular and respiratory systems in conscious rabbits. Morphine (4 mg/kg i.v.) caused analgesia, bradycardia, hypotension and respiratory depression, as indicated by a fall in respiratory rate of
Zhenyu Wu et al.
Evidence-based complementary and alternative medicine : eCAM, 2016, 5616905-5616905 (2016-07-19)
This study was designed to investigate the effect of Aurantii fructus immaturus flavonoid (AFIF) on the contraction of isolated gastric smooth muscle in rats and explore its underlying mechanisms. Isolated antral longitudinal smooth muscle strip (ALSMS) and pyloric circular smooth
Modified carbon paste sensor for the potentiometric determination of neostigmine bromide in pharmaceutical formulations, human plasma and urine
Khorshid, A F and Issa, Y M
Biosensors And Bioelectronics, 51, 143-149 (2014)
Differentiation and induced sensorial alteration of the coronal organ in the asexual life of a tunicate
Manni L, et al.
Integrative and Comparative Biology, 58(2), 317-328 (2018)
Effect of aurantii fructus immaturus flavonoid on the contraction of isolated gastric smooth muscle strips in rats
Wu Z, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2016(2), 317-328 (2016)
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