O8382
17-Octadecynoic acid
≥95% (GC), Cytochrome P450 epoxygenase inhibitor, powder
동의어(들):
17-ODYA, Alkynyl Stearic Acid, Octadec-17-ynoic acid
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C18H32O2
CAS 번호:
Molecular Weight:
280.45
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
17-Octadecynoic acid, ≥95% (GC)
SMILES string
C#CCCCCCCCCCCCCCCCC(O)=O
InChI
1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h1H,3-17H2,(H,19,20)
InChI key
DZIILFGADWDKMF-UHFFFAOYSA-N
assay
≥95% (GC)
form
powder
solubility
chloroform: 10 mg/mL to clear, colorless to faintly yellow
Quality Level
Application
17-Octadecynoic acid has been used in lipid synthesis.
Biochem/physiol Actions
17-Octadecynoic acid (7-ODYA) is an irreversible inhibitor of cytochrome P450 isozymes, that participates in long-chain fatty acid metabolism.
Suicide substrate inhibitor that selectively and irreversibly inhibits cytochrome P450 epoxygenases and ω-hydrolases.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Effects of intrarenal infusion of 17-octadecynoic acid on renal antihypertensive mechanisms in anesthetized rabbits
Evans R G, et al.
American Journal of Hypertension, 11(7), 803-812 (1998)
M H Wang et al.
The Journal of pharmacology and experimental therapeutics, 284(3), 966-973 (1998-03-13)
We characterized the inhibitory activity of several acetylenic and olefinic compounds on cytochrome P450 (CYP)-derived arachidonic acid omega-hydroxylation and epoxidation using rat renal cortical microsomes and recombinant CYP proteins. Among the acetylenic compounds, 6-(2-propargyloxyphenyl)hexanoic acid (PPOH) and N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide were found
Kristina Hofmann et al.
Scientific reports, 7(1), 10779-10779 (2017-09-09)
The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell types. While the major function of oligodendrocytes is the
Lu Wei et al.
Nature methods, 11(4), 410-412 (2014-03-04)
Sensitive and specific visualization of small biomolecules in living systems is highly challenging. We report stimulated Raman-scattering imaging of alkyne tags as a general strategy for studying a broad spectrum of small biomolecules in live cells and animals. We demonstrate
Mamta Fuloria et al.
American journal of physiology. Lung cellular and molecular physiology, 283(2), L383-L389 (2002-07-13)
We examined the responses of newborn piglet pulmonary resistance arteries (PRAs) to 5,6-epoxyeicosatrienoic acid (5,6-EET), a cytochrome P-450 metabolite of arachidonic acid. In PRAs preconstricted with a thromboxane A(2) mimetic, 5,6-EET caused a concentration-dependent dilation. This dilation was partially inhibited
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