P2980
Pertussis toxin
from Bordetella pertussis, buffered aqueous glycerol solution, protein endotoxin
동의어(들):
Histamine-sensitizing factor, IAP, Islet Activating Protein, PTX, Pertussigen
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Form:
buffered aqueous glycerol solution
Quality level:
제품 이름
Pertussis toxin from Bordetella pertussis, buffered aqueous glycerol solution
description
aseptically packaged
Quality Level
form
buffered aqueous glycerol solution
shipped in
dry ice
storage temp.
−20°C
SMILES string
O(C)C(=O)CCCCCCCCCCCCCCCCCCCCCCCC
InChI
1S/C26H52O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28-2/h3-25H2,1-2H3
InChI key
WOPKHAQDUMDJIY-UHFFFAOYSA-N
Gene Information
Bordetella pertussis Tohama I ... ptxA(2665068), ptxB(2665069), ptxC(2665408)
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General description
Pertussis (Pertussis) toxin (PTX) is a protein isolated from the bacterium Bordatella (Bordatella) coccobaccillus. The toxin is excreted in a non-active state. When the B oligomer of the bacterium, Bordatella coccobacillus, comes in contact with the cell membrane, an S1 subunit of its A protomer is activated. This activation may be mediated by glutathione and/or ATP.
Application
Inactive toxin form released from B. pertussis.
Pertussis toxin from Bordetella pertussis has been used: to enhance cardiac myosin immunization of rats to induce myocarditis; to break down the blood–brain barrier in the Cuprizone and cuprizone/MOG-EAE model; as an inhibitor of Gαi signaling
The toxin is released from B. pertussis in an inactive form. When the pertussis toxin B oligomer binds to the cell membrane, the S1 subunit of its A protomer becomes activated, perhaps through the action of glutathione and ATP. A protocol for activating pertussis toxin in vitro is given by Kaslow, et al.
Biochem/physiol Actions
Pertussis toxin catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt.
Pertussis toxin catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt. This prevents the G protein heterotrimers from interacting with receptors, thus blocking their coupling and activation. Since the Gα subunits remain in their GDP-bound, inactive state, they are unable to inactivate adenylyl cyclase or open K+ channels.
Features and Benefits
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Physical form
Aseptically filled solution in 50% glycerol, containing 50 mM TRIS, 10 mM glycine, 0.5 M NaCl, pH 7.5
저장 등급
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Journal of molecular and cellular cardiology, 121, 60-68 (2018-07-04)
G-protein receptor kinases (GRKs) regulate adult hearts by modulating inotropic, chronotropic and hypertrophic signaling of 7-transmembrane spanning neurohormone receptors. GRK-mediated desensitization and downregulation of β-adrenergic receptors has been implicated in adult heart failure; GRKs are therefore a promising therapeutic target.
Su Jin Hwang et al.
Laboratory investigation; a journal of technical methods and pathology, 90(1), 9-19 (2009-10-14)
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Jonathan Hoggatt et al.
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문서
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
고리형 AMP(cAMP), 고리형 GMP(cGMP), 고리형 ADP-리보스를 포함하여 고리형 뉴클레오타이드는 GPCR 활성화에 의해 개시된 세포내 이벤트의 2차 전달자로서 광범위하게 연구되었습니다. cAMP는 주로 cAMP 의존성 단백질 인산화효소(PKA)의 활성화를 통해 모든 진핵생물 세포에서 세포 기능을 변형시키지만 cAMP 개폐 이온 채널 및 cAMP에 의해 직접 활성화되는 구아닌 뉴클레오타이드 교환 인자를 통해서도 변형시킵니다.
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