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Merck

P5585

Palmitic acid

BioXtra, ≥99%

동의어(들):

1-Pentadecanecarboxylic acid, C16:0, Cetylic acid, Hexadecanoic acid, NSC 5030, PamOH

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
CH3(CH2)14COOH
CAS 번호:
57-10-3
Molecular Weight:
256.42
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
24898674
EC Number:
200-312-9
Beilstein/REAXYS Number:
607489
MDL number:
MFCD00002747
Assay:
≥99%
Form:
powder
Grade:
BioPerformance Certified

주요 문서

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InChI

1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

InChI key

IPCSVZSSVZVIGE-UHFFFAOYSA-N

SMILES string

CCCCCCCCCCCCCCCC(O)=O

biological source

plant (vegetable)

grade

BioPerformance Certified

vapor pressure

10 mmHg ( 210 °C)

product line

BioXtra

assay

≥99%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

ign. residue

≤0.1%

bp

271.5 °C/100 mmHg (lit.)

mp

61-62.5 °C (lit.)

solubility

chloroform: 0.5 M, clear, colorless

density

0.852 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.005%, Ca: ≤0.0005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH4+: ≤0.05%, Na: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.0005%

functional group

carboxylic acid

lipid type

saturated FAs

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... FABP2(2169), FABP3(2170), FABP4(2167), FABP5(2171)

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관련 카테고리

Application

Palmitic acid has been used:
  • as a medium supplement in chorionic villous tissue culture form placenta
  • as a component of hormone pellet for implantation in mice ovary
  • for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1

Biochem/physiol Actions

Palmitic acid (PA) is a component of membrane phospholipids (PL) and adipose triacylglycerols (TAG). Elevated levels of palmitic acid contributes to the pathophysiology of atherosclerosis, type 2 diabetes mellitus, neurodegenerative diseases, obesity and cancer. PA promotes apoptosis in the endothelial cell by modulating the p38 mitogen-activated protein kinase (MAPK) pathway and favors expression of TNF-α and reactive oxygen species accumulation. PA promotes interleukin 8 (IL-8) synthesis in hepatocytes contributing to hepatic inflammation. PA by interacting with toll-like receptor 4 (TLR4) induces inflammatory injury in cardiomyoctes.
Palmitic acid is a straight-chain 16-carbon fatty acid. Diets rich in palmitic acid, along with lauric and myristic acids, are associated with increased serum levels of low-density lipoprotein cholesterol. Palmitic acid is the first fatty acid produced by lipogenesis. It is a negative regulator of acetyl-CoA carboxylase (ACC) and is implicated in fatty acid-induced insulin resistance.

저장 등급

11 - Combustible Solids

wgk

nwg

flash_point_f

235.4 °F

flash_point_c

113 °C

ppe

dust mask type N95 (US), Eyeshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
SLBM8964V
SLBM8964V
SLCL6353
SLCJ5980
SLCH4845

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Lipidomic Analysis of alpha Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
Fanning S, et al.
Molecular Cell (2018)
Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
Joshi-Barve S, et al.
Hepatology, 46(3), 823-830 (2007)
Cangju Qinggan Jiangzhi Decoction Reduces the Development of NonAlcoholic Steatohepatitis and Activation of Kupffer Cells
Cheng Y, et al.
Cellular Physiology and Biochemistry, 48(3), 971-982 (2018)
Biological and nutritional properties of palm oil and palmitic acid: effects on health
Mancini A, et al.
Molecules (Basel), 20(9), 17339-17361 (2015)
Palmitic acid induced vascular endothelial cell apoptosis contributes to the high severity of coronary artery disease in the Uygur population
Jiang H, et al.
Biomedical Research, 28(2), 17339-17361 (2017)
모든 관련된 서류 보기

문서

Lipid-induced Insulin Resistance

Lipid Induced Insulin Resistance

Fatty Acid Synthesis in Cancer Cells

Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.

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