P6254
Prednisone
≥98% (HPLC), powder, anti-inflammatory activity
동의어(들):
1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C21H26O5
CAS 번호:
Molecular Weight:
358.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-160-3
MDL number:
Beilstein/REAXYS Number:
2065301
제품 이름
Prednisone, ≥98%
biological source
synthetic
Quality Level
sterility
non-sterile
assay
≥98%
form
powder
mp
236-238 °C (lit.)
solubility
chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to light yellow
application(s)
hematology
shipped in
ambient
storage temp.
room temp
SMILES string
O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1
InChI
1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
InChI key
XOFYZVNMUHMLCC-ZPOLXVRWSA-N
Gene Information
human ... NR3C1(2908)
Application
Prednisone has been used in dimethyl sulfoxide stock suspension to inject into experimental mice and to analyze the effects of glucocorticoid steroid. It has also been used as a test drug, formulated with peanut butter to study the effects of daily administration of MIDD0301, by animal weight, organ weight and haematological analysis.
Biochem/physiol Actions
Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activity. It is useful in treating many disease states and has a half-life of 3.4 to 3.8 hours in plasma. Prednisone is metabolized to prednisolone, which is physiologically active.
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
pcodes
Hazard Classifications
STOT RE 2
저장 등급
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Intermittent glucocorticoid dosing improves muscle repair and function in mice with limb-girdle muscular dystrophy
Quattrocelli M, et al.
The American Journal of Pathology, 187(11), 2520-2535 (2017)
MIDD 0301-A first-in-class anti-inflammatory asthma drug targets GABAA receptors without causing systemic immune suppression
Zahn NM, et al.
Basic and Clinical Pharmacology and Toxicology (2019)
Saunders Handbook of Veterinary Drugs - E-Book, 4(2), 645-645 (2010)